Department of Parasitology and Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Acta Trop. 2010 Jul-Aug;115(1-2):69-76. doi: 10.1016/j.actatropica.2009.12.007. Epub 2010 Jan 4.
In this study, we investigated the anthelmintic activity of [6]-gingerol, [10]-shogaol, [10]-gingerol, [6]-shogaol and hexahydrocurcumin, a constituent isolate from the roots of ginger (Zingiber officinale), for the parasite Angiostrongylus cantonensis. This study found that the above constituents killed A. cantonensis larvae or reduced their spontaneous movements in a time- and dose-dependent manner. The larvicidal effect or ability to halt spontaneous parasite movement of [10]-shogaol, [6]-gingerol, [10]-gingerol, [6]-shogaol and hexahydrocurcumin at various concentrations was reached from 24 to 72 h, respectively. Further investigation to determine minimal effective doses of [10]-gingerol and hexahydrocurcumin revealed [10]-gingerol to have a greater maximum larvicidal effect and loss of spontaneous movements than hexahydrocurcumin, mebendazole and albendazole. These constituents of ginger showed effects against DPPH and peroxyl radical under larvicidal effect. Together, these findings suggest that these constituents of ginger might be used as larvicidal agents against A. cantonensis.
在这项研究中，我们研究了 [6]-姜酚、[10]-姜烯酚、[10]-姜醇、[6]-姜烯酚和六氢姜黄素（从生姜（Zingiber officinale）的根部分离得到的成分）对寄生虫广州管圆线虫的驱虫活性。本研究发现，上述成分能以时间和剂量依赖的方式杀死广州管圆线虫幼虫或减少其自发运动。[10]-姜烯酚、[6]-姜酚、[10]-姜醇、[6]-姜烯酚和六氢姜黄素在不同浓度下的杀幼虫作用或阻止寄生虫自发运动的能力分别在 24 至 72 小时达到。进一步确定[10]-姜醇和六氢姜黄素的最小有效剂量的研究表明，[10]-姜醇的最大杀幼虫效果和自发运动丧失比六氢姜黄素、甲苯达唑和阿苯达唑更大。生姜的这些成分在杀幼虫作用下对 DPPH 和过氧自由基表现出了作用。综上所述，这些研究结果表明，生姜的这些成分可能被用作对抗广州管圆线虫的杀幼虫剂。
