Institute for Surgical Pathology, University Hospital Zurich, Zurich, Switzerland.
BMC Cancer. 2010 Jun 9;10:273. doi: 10.1186/1471-2407-10-273.
Expression of periostin is an indicator of epithelial-mesenchymal transition in cancer but a detailed analysis of periostin expression in prostate cancer has not been conducted so far.
Here, we evaluated periostin expression in prostate cancer cells and peritumoural stroma immunohistochemically in two independent prostate cancer cohorts, including a training cohort (n = 93) and a test cohort (n = 325). Metastatic prostate cancers (n = 20), hormone refractory prostate cancers (n = 19) and benign prostatic tissues (n = 38) were also analyzed.
In total, strong epithelial periostin expression was detectable in 142 of 418 (34.0%) of prostate carcinomas and in 11 of 38 benign prostate glands (28.9%). Increased periostin expression in carcinoma cells was significantly associated with high Gleason score (p < 0.01) and advanced tumour stage (p < 0.05) in the test cohort. Whereas periostin expression was weak or absent in the stroma around normal prostate glands, strong periostin expression in tumour stroma was found in most primary and metastatic prostate cancers. High stromal periostin expression was associated with higher Gleason scores (p < 0.001). There was a relationship between stromal periostin expression and shortened PSA relapse free survival times in the training cohort (p < 0.05).
Our data indicate that periostin up-regulation is related to increased tumour aggressiveness in prostate cancer and might be a promising target for therapeutical interventions in primary and metastatic prostate cancer.
periostin 的表达是癌症中上皮间质转化的一个指标，但迄今为止，尚未对前列腺癌中的 periostin 表达进行详细分析。
在这里，我们通过免疫组织化学方法在两个独立的前列腺癌队列中评估了前列腺癌细胞和肿瘤周围基质中的 periostin 表达，包括一个训练队列（n = 93）和一个测试队列（n = 325）。还分析了转移性前列腺癌（n = 20）、激素难治性前列腺癌（n = 19）和良性前列腺组织（n = 38）。
在总共 418 例前列腺癌中，有 142 例（34.0%）和 38 例良性前列腺组织中的 11 例（28.9%）可检测到上皮性 periostin 强表达。在测试队列中，癌细胞中periostin 表达的增加与高 Gleason 评分（p < 0.01）和晚期肿瘤分期（p < 0.05）显著相关。虽然正常前列腺周围基质中的 periostin 表达较弱或缺失，但在大多数原发性和转移性前列腺癌中发现肿瘤基质中有强的 periostin 表达。基质中periostin 的高表达与较高的 Gleason 评分相关（p < 0.001）。在训练队列中，基质中periostin 表达与 PSA 无复发生存时间缩短之间存在相关性（p < 0.05）。
我们的数据表明，periostin 的上调与前列腺癌中肿瘤侵袭性的增加有关，可能是原发性和转移性前列腺癌治疗干预的一个有前途的靶点。
