Department of Physiology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China.
Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University, Guiyang, China.
Int J Public Health. 2022 Aug 24;67:1604616. doi: 10.3389/ijph.2022.1604616. eCollection 2022.
Cervical cancer is a serious potential risk to women's health, and is closely related to persistent HPV infection. Vitamin K mainly existed in green vegetables, fruit, and dairy products. This research aims to observe the association between vitamin K and HPV-infection. 13,447 participants from the NHANES were selected. Dietary vitamin K intake was used as the objective independent variable and continuous variable, HPV-infection status was used as the outcome variable, and characteristics of selected participants were used as the covariates. There was a nonlinearity between vitamin K intake and HPV-infection, and the inflection point is 3.81 of log2 vitamin K intake. In a range of 0-3.81, Each one-unit increase in log2 vitamin K intake was associated with a 43% reduction in the risk of HPV infection. When log2 vitamin K intake excess of 3.81, the risk of HPV infection did not continue to decline. The HPV-subtype was not associated with vitamin K intake. There is a nonlinearity between vitamin K intake and HPV-infection status. But HPV-subtype was not associated with vitamin K intake.
宫颈癌是严重威胁女性健康的潜在风险因素，与 HPV 持续感染密切相关。维生素 K 主要存在于绿色蔬菜、水果和奶制品中。本研究旨在观察维生素 K 与 HPV 感染之间的关系。从 NHANES 中选择了 13447 名参与者。膳食维生素 K 摄入量作为客观的自变量和连续变量，HPV 感染状态作为因变量，选择参与者的特征作为协变量。维生素 K 摄入量与 HPV 感染之间存在非线性关系，拐点为维生素 K 摄入量的 3.81 的对数 2。在 0-3.81 的范围内，log2 维生素 K 摄入量每增加一个单位，HPV 感染的风险就会降低 43%。当 log2 维生素 K 摄入量超过 3.81 时，HPV 感染的风险不会继续下降。HPV 亚型与维生素 K 摄入量无关。维生素 K 摄入量与 HPV 感染状态之间存在非线性关系。但是，HPV 亚型与维生素 K 摄入量无关。
