穿越胚胎中线：调控轴突在中间靶点反应性的分子机制。
Crossing the embryonic midline: molecular mechanisms regulating axon responsiveness at an intermediate target.
作者信息
Neuhaus-Follini Alexandra, Bashaw Greg J
机构信息
Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
出版信息
Wiley Interdiscip Rev Dev Biol. 2015 Jul-Aug;4(4):377-89. doi: 10.1002/wdev.185. Epub 2015 Mar 16.
Abstract
In bilaterally symmetric animals, the precise assembly of neural circuitry at the midline is essential for coordination of the left and right sides of the body. Commissural axons must first be directed across the midline and then be prevented from re-crossing in order to ensure proper midline connectivity. Here, we review the attractants and repellents that direct axonal navigation at the ventral midline and the receptors on commissural neurons through which they signal. In addition, we discuss the mechanisms that commissural axons use to switch their responsiveness to midline-derived cues, so that they are initially responsive to midline attractants and subsequently responsive to midline repellents.
摘要
在两侧对称动物中，神经回路在中线处的精确组装对于身体左右两侧的协调至关重要。连合轴突必须首先被引导穿过中线，然后被阻止再次穿过，以确保正确的中线连接。在这里，我们回顾了引导轴突在腹侧中线导航的吸引剂和排斥剂，以及连合神经元上它们借以发出信号的受体。此外，我们还讨论了连合轴突用来切换其对中线衍生信号反应性的机制，以便它们最初对中线吸引剂有反应，随后对中线排斥剂有反应。
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