Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Am J Hypertens. 2011 Sep;24(9):1007-14. doi: 10.1038/ajh.2011.91. Epub 2011 Jun 9.
The purpose of this study was to determine whether relationships between alcohol intake and atherosclerotic risk factors were different in normotensive and prehypertensive persons.
Japanese men aged 35-60 years who showed normal blood pressure (n = 4,778) or prehypertension (n = 9,728) without any drug therapy for hypertension were divided into non, light (<22 g ethanol/day), heavy (≥ 22 and < 44 g ethanol/day) and very heavy (≥ 44 g ethanol/day) drinkers.
In subjects with prehypertension, body mass index (BMI) and waist circumference were significantly lower and smaller, respectively, in light, heavy and very heavy drinkers than in nondrinkers. In subjects with normal blood pressure, BMI was significantly lower in light and heavy drinkers but not in very heavy drinkers than in nondrinkers, and waist circumference was not significantly different in non, light and heavy drinkers and was significantly larger in very heavy drinkers than in nondrinkers. Both in the prehypertensive and normotensive groups, compared with nondrinkers, hemoglobin A(1C) and low-density lipoprotein (LDL) cholesterol were significantly lower and high-density lipoprotein (HDL) cholesterol was significantly higher in light, heavy and very heavy drinkers, and log-converted triglycerides was significantly higher in very heavy drinkers.
The association of alcohol intake with a lower occurrence of obesity is stronger in prehypertensives than in normotensives, while the associations of alcohol intake with lower occurrences of hyperglycemia and abnormal cholesterol profile, such as lowered HDL cholesterol and elevated LDL cholesterol, and a higher occurrence of elevated triglycerides are similar in normotensive and prehypertensive persons.
本研究旨在确定饮酒与动脉粥样硬化危险因素之间的关系在血压正常和高血压前期人群中是否不同。
本研究纳入了年龄在 35-60 岁之间、血压正常（n=4778）或高血压前期（n=9728）且未接受任何高血压药物治疗的日本男性，将他们分为不饮酒者、轻饮酒者（<22 g 乙醇/天）、中重度饮酒者（≥22 且<44 g 乙醇/天）和重度饮酒者（≥44 g 乙醇/天）。
在高血压前期人群中，与不饮酒者相比，轻、中重度饮酒者的体重指数（BMI）和腰围分别明显更低和更小。在血压正常人群中，与不饮酒者相比，轻、中重度饮酒者的 BMI 明显更低，但重度饮酒者的 BMI 与不饮酒者无显著差异，而轻、中重度饮酒者的腰围与不饮酒者无显著差异，重度饮酒者的腰围明显大于不饮酒者。在高血压前期和血压正常两组人群中，与不饮酒者相比，轻、中、重度饮酒者的血红蛋白 A1c（HbA1c）和低密度脂蛋白（LDL）胆固醇明显更低，高密度脂蛋白（HDL）胆固醇明显更高，重度饮酒者的 log 转化甘油三酯明显更高。
与不饮酒者相比，饮酒与肥胖发生风险降低的相关性在高血压前期人群中更强，而饮酒与高血糖和异常胆固醇谱（如降低 HDL 胆固醇和升高 LDL 胆固醇）发生风险降低以及甘油三酯升高风险升高的相关性在血压正常和高血压前期人群中相似。
