Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Hyogo, Japan.
Gerontology. 2012;58(1):24-31. doi: 10.1159/000323080. Epub 2011 Jan 26.
Relationships between alcohol consumption and risks for metabolic syndrome in general populations are very controversial. It is unknown whether age influences the relationship between alcohol intake and the prevalence of metabolic syndrome.
The purpose of this study was to determine whether age influences the relationship between alcohol consumption and metabolic syndrome.
Men aged ≥35 and <45 years (younger group) and those aged ≥65 years (older group), matched for alcohol intake and smoking history, were divided into four subgroups by alcohol intake [non-, light (<22 g ethanol/day), heavy (≥22 and <44 g ethanol/day) and very heavy (≥44 g ethanol/day) drinkers]. Odds ratios (ORs) versus nondrinkers for each risk factor and metabolic syndrome were compared between the younger and older groups.
Both in the younger and older groups, ORs for high blood pressure and low HDL cholesterol were significantly high and low, respectively, in all drinker groups. In younger subjects, the OR for large waist circumference was significantly low in light drinkers, and the OR for high hemoglobin A(1c) was significantly low in light and heavy drinkers, while these associations were not found in older subjects. The OR for metabolic syndrome was significantly low in light and heavy drinkers in the younger subjects but was not significant in any drinker groups in older subjects.
Age influences the relationships between alcohol consumption and atherosclerotic risk factors, and there is a significant association between alcohol intake and a lower risk for metabolic syndrome in young men but not in elderly men.
饮酒与一般人群代谢综合征风险之间的关系存在很大争议。目前尚不清楚年龄是否会影响饮酒与代谢综合征之间的关系。
本研究旨在确定年龄是否会影响饮酒与代谢综合征之间的关系。
将年龄≥35 岁且<45 岁（年轻组）和年龄≥65 岁（老年组）的男性，按照饮酒量和吸烟史相匹配，分为非饮酒者、轻度饮酒者（<22 g 乙醇/天）、重度饮酒者（≥22 且<44 g 乙醇/天）和极重度饮酒者（≥44 g 乙醇/天）四个亚组。比较年轻组和老年组之间各危险因素和代谢综合征的非饮酒者比值比（OR）。
在年轻组和老年组中，所有饮酒组的高血压和低 HDL 胆固醇的 OR 均显著升高和降低。在年轻组中，轻中度饮酒者的大腰围 OR 显著降低，轻、重度饮酒者的血红蛋白 A1c 水平 OR 显著降低，而在老年组中则没有发现这些关联。在年轻组中，轻、重度饮酒者的代谢综合征 OR 显著降低，但在老年组的任何饮酒组中均不显著。
年龄会影响饮酒与动脉粥样硬化危险因素之间的关系，在年轻男性中，饮酒与代谢综合征风险降低之间存在显著关联，但在老年男性中则没有。
