Hirakawa Miharu, Arase Yasuji, Amakawa Kazuhisa, Ohmoto-Sekine Yuki, Ishihara Makiko, Shiba Masato, Ogawa Kyoko, Okuda Chikao, Jinno Toyohisa, Kato Hisahito, Tsuji Hiroyuki, Hashimoto Mitsuyo, Yamamoto Takashi, Arimoto Satao, Hara Shigeko
Health Management Center, Toranomon Hospital, Japan.
Intern Med. 2015;54(17):2139-45. doi: 10.2169/internalmedicine.54.2736. Epub 2015 Sep 1.
The precise relationship between alcohol intake and metabolic syndrome (MetS) is still unclear, and the results from previous studies have been inconclusive. Thus, we examined the effect of alcohol intake on the risk of MetS in men in order to gain more information on a potential relationship.
This study included 22,349 men who were divided into four groups according to their average alcohol intake [non-, light (less than 20 g ethanol/day), heavy (equal or more than 20 g and less than 60 g ethanol/day) and very heavy (equal and greater than 60 g ethanol/day) drinkers]. We measured each subject's body mass index (BMI), waist circumference and blood pressure (BP) and conducted a blood test to obtain a complete blood count and biochemical panel. These results were used to obtain the MetS prevalence. Additionally, fatty liver was diagnosed using abdominal ultrasonography.
Light drinkers had smaller waist circumferences. Heavy and very heavy drinkers had larger waist circumferences, a higher BMI, a higher BP, higher fasting plasma glucose levels, higher triglycerides (TG) levels and higher high-density lipoprotein (HDL) cholesterol levels while they had lower low-density lipoprotein cholesterol levels than nondrinkers. The prevalence of high BP, hyperglycemia and high TG was significantly higher in heavy and very heavy drinkers than in nondrinkers. The prevalence of low HDL cholesterol levels decreased with an increase in alcohol consumption. The prevalence of MetS was significantly lower in light drinkers and higher in very heavy drinkers compared with nondrinkers.
Alcohol intake significantly influences the risk of MetS in men. A significant association was seen between an alcohol intake of 60 g/day or higher and the prevalence of MetS.
酒精摄入量与代谢综合征（MetS）之间的确切关系仍不清楚，先前研究的结果尚无定论。因此，我们研究了酒精摄入量对男性患MetS风险的影响，以便获取更多关于潜在关系的信息。
本研究纳入了22349名男性，根据他们的平均酒精摄入量分为四组[不饮酒者、轻度饮酒者（每天乙醇摄入量少于20克）、重度饮酒者（每天乙醇摄入量等于或超过20克且少于60克）和极重度饮酒者（每天乙醇摄入量等于或超过60克）]。我们测量了每位受试者的体重指数（BMI）、腰围和血压（BP），并进行了血液检测以获取全血细胞计数和生化指标。这些结果用于计算MetS患病率。此外，通过腹部超声诊断脂肪肝。
轻度饮酒者腰围较小。重度和极重度饮酒者腰围较大，BMI较高，血压较高，空腹血糖水平较高，甘油三酯（TG）水平较高，高密度脂蛋白（HDL）胆固醇水平较高，而低密度脂蛋白胆固醇水平低于不饮酒者。重度和极重度饮酒者的高血压、高血糖和高TG患病率显著高于不饮酒者。HDL胆固醇水平降低的患病率随酒精摄入量增加而降低。与不饮酒者相比，轻度饮酒者的MetS患病率显著较低，极重度饮酒者的MetS患病率较高。
酒精摄入量显著影响男性患MetS的风险。每天饮酒60克或以上与MetS患病率之间存在显著关联。
