Sakata T
Department of Internal Medicine I, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Agents Actions Suppl. 1991;33:91-6. doi: 10.1007/978-3-0348-7309-3_7.
Effects of hypothalamic histamine on food intake and adaptive behavior to altered ambient temperature were assessed in rats by manipulating histamine endogenously. Infusion of a-fluoromethylhistidine (FMH) into the third cerebroventricle elicited meals dose dependently (p less than 0.01), when hypothalamic histamine was normally high. The effect of FMH was attenuated, and thioperamide conversely suppressed food intake (p less than 0.05), when the probes were performed during the minimum histamine content. The ventromedial hypothalamus and the paraventricular nucleus were identified as the active target loci. Hypothalamic histamine level was lowered at 4 degrees C and raised at 31 degrees C ambient temperature. FMH attenuated both the elevated histamine level and adaptive behavior at 31 degrees C. Neuronal histamine may play a physiological role in feeding suppression through those hypothalamic nuclei, and also in adaptive behavior in abnormal ambient temperature.
通过内源性调控组胺，在大鼠中评估下丘脑组胺对食物摄入及对环境温度改变的适应性行为的影响。当下丘脑组胺水平正常较高时，向第三脑室注入α-氟甲基组氨酸（FMH）可剂量依赖性地引发进食（p<0.01）。当在组胺含量最低时进行检测，FMH的作用减弱，而硫代哌啶则相反地抑制食物摄入（p<0.05）。腹内侧下丘脑和室旁核被确定为活跃的靶点。在4摄氏度时下丘脑组胺水平降低，在31摄氏度环境温度时升高。FMH减弱了31摄氏度时升高的组胺水平及适应性行为。神经元组胺可能通过那些下丘脑核团在进食抑制中发挥生理作用，并且在异常环境温度下的适应性行为中也发挥作用。
