Minamikawa M, Yamamoto K, Okuma H, Uyama M
Department of Ophthalmology, Kansai Medical University, Moriguchi, Japan.
Nippon Ganka Gakkai Zasshi. 1991 Feb;95(2):123-9.
Experimental retinal branch vein occlusion in monkeys (macaca irus) were produced by yellow wavelength (577nm) dye laser photocoagulation. The clinical sequence was observed in terms of the structural and ultrastructural findings occurring during the natural history of experimental branch vein occlusion, particularly in the early stage. Immediately after the occlusion, venous dilatation and retinal edema and hemorrhage appeared. Extravascular leakage of dye in fluorescein angiography and hemorrhage appeared from small venules at an early stage. Leakage from the larger vessels was observed later. Opening of the intercellular junctional complexes, which signifies breakdown of the blood-retinal barrier was detected by electron microscopy. Subsequently degenerative or necrotic changes in endothelial cells appeared with the formation of intravascular thrombi and extravascular leakage of blood components appeared from these vessels.
通过黄色波长（577nm）染料激光光凝法在猕猴（食蟹猴）中制造实验性视网膜分支静脉阻塞。根据实验性分支静脉阻塞自然病程中出现的结构和超微结构发现，特别是在早期阶段，观察临床过程。阻塞后立即出现静脉扩张、视网膜水肿和出血。在早期，荧光素血管造影中染料的血管外渗漏和小静脉出血出现。后来观察到较大血管的渗漏。通过电子显微镜检测到细胞间连接复合体的开放，这表明血视网膜屏障的破坏。随后，内皮细胞出现退行性或坏死性变化，形成血管内血栓，这些血管出现血液成分的血管外渗漏。
