Minamikawa M, Yamamoto K, Okuma H, Uyama M
Department of Ophthalmology, Kansai Medical University, Moriguchi, Japan.
Nippon Ganka Gakkai Zasshi. 1993 Mar;97(3):351-9.
Retinal branch vein occlusion was experimentally produced in monkey (macaca irus) by dye laser photocoagulation. Venous dilatation, retinal edema and punctate hemorrhages were the ophthalmoscopic changes immediately after the occurrence of venous occlusion by photocoagulation. Fluorescein angiography revealed delay of retinal circulation and dye leakage from these venules. Fluorescein angiography on the 2nd day revealed caliber irregularities in the venules distal to the photocoagulated points. Histopathologically, thrombus formation and partial defect of the endothelial cells were observed in the venules in the areas which showed recovery with immature endothelial cells on the 4th day. Young endothelial cells proliferating along the endothelial basement membrane, which remained around the thrombi, and recanalization were observed on the 7th day. These results reveals a process of recanalization in the thrombogenous retinal venous occlusion.
通过染料激光光凝在猴（猕猴）身上实验性制造视网膜分支静脉阻塞。光凝导致静脉阻塞后立即出现的眼底镜改变为静脉扩张、视网膜水肿和点状出血。荧光素血管造影显示视网膜循环延迟以及这些小静脉有染料渗漏。第2天的荧光素血管造影显示光凝点远端小静脉管径不规则。组织病理学检查发现，在第4天显示恢复且有未成熟内皮细胞的区域，小静脉中有血栓形成和内皮细胞部分缺损。在第7天观察到年轻的内皮细胞沿血栓周围残留的内皮基底膜增殖以及再通。这些结果揭示了血栓形成性视网膜静脉阻塞中的再通过程。
