Naresh V V S, Reddy A L K, Sivaramakrishna G, Sharma P V G K, Vardhan R V, Kumar V Siva
Department of Nephrology, Sri Venkateswara Institute of Medical Sciences, Sri Venkateswara University, Tirupati - 517 507, India.
Indian J Nephrol. 2009 Oct;19(4):145-8. doi: 10.4103/0971-4065.59335.
Nephropathy is an important and a frequent complication of long-term type II diabetic nephropathy. Strong evidence exists that genetic predisposition plays a major role in the development of diabetic nephropathy. Recent studies have implicated association between angiotensin converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and nephropathy. The deletion gene polymorphism of ACE gene has been shown to be associated with increased activity of this enzyme. This study examines the association of ACE I/D polymorphism with type II diabetes without nephropathy in 30 patients and type II diabetes with nephropathy in 30 patients. The results of the study suggest the association between the DD polymorphism and type II diabetes with nephropathy.
肾病是长期II型糖尿病常见的重要并发症。有充分证据表明遗传易感性在糖尿病肾病的发生发展中起主要作用。最近的研究表明血管紧张素转换酶（ACE）插入/缺失（I/D）基因多态性与肾病之间存在关联。已证明ACE基因的缺失基因多态性与该酶活性增加有关。本研究调查了30例无肾病的II型糖尿病患者和30例有肾病的II型糖尿病患者中ACE I/D多态性的情况。研究结果提示DD基因多态性与有肾病的II型糖尿病之间存在关联。
