Hermann Buhl Institute for Hypoxia and Sleep Medicine Research, Paracelsus Medical University, Salzburg, Austria.
Sleep Breath. 2010 Sep;14(3):221-5. doi: 10.1007/s11325-010-0342-7. Epub 2010 Jun 10.
In several investigations on mountaineers under moderate hypoxia, at altitudes between 2,500 m and 4,500 m, weight loss occurs, fat levels in the serum and insulin resistance (in diabetic mountaineers) are reduced. Animal studies with different time dosage regimens of hypoxia in animal cages revealed different and partly confusing results regarding fat metabolism under hypoxia.
Hypothesis for the change in glucose and fat metabolism include a HIF promoted higher leptin rate under hypoxia and an increased glucose transport in peripheral organs.
This short review discusses some of the different investigations in this topic. In a second part it is shown how studies of metabolism in yeast cells with an upregulated glycolysis in the cell itself under hypoxic conditions could help to better understand metabolic changes under hypoxia.
在对海拔 2500 米至 4500 米之间的中度低氧环境下登山者进行的多项研究中，体重减轻，血清脂肪水平降低，胰岛素抵抗（糖尿病登山者）得到改善。在动物缺氧笼中进行的不同时间剂量方案的动物研究显示，在缺氧条件下脂肪代谢的结果不同，部分结果令人困惑。
葡萄糖和脂肪代谢变化的假说包括缺氧下 HIF 促进更高的瘦素率和外周器官葡萄糖转运增加。
这篇简短的综述讨论了该主题的一些不同研究。在第二部分中，展示了在缺氧条件下细胞内糖酵解上调的酵母细胞代谢研究如何帮助更好地理解缺氧下的代谢变化。
