Suzuki Hayato, Fukushima Takao, Makino Kunihiko, Kuwabara Takeo
Department of Neurology, Shibata Hospital-Niigata Preferctural Hospital.
Rinsho Shinkeigaku. 2010 May;50(5):329-31. doi: 10.5692/clinicalneurol.50.329.
We report the case of a 29-year-old man, who could not remember some words of Kanji and showed emotional instability. Magnetic resonance imaging (MRI) scan of his brain appeared normal. Cerebrospinal fluid (CSF) analysis showed lymphocytic pleocytosis. An electroencephalogram (EEG) showed slow activities in both frontal regions of the brain. He was diagnosed as acute encephalitis. On his fourth hospital day, he was found to be catatonic and showed mutism, akinetism, and catalepsy. On the ninth day, he showed hyperpyrexia, muscle rigidity, difficulty in swallowing, respiratory insufficiency, and rhabdomyolysis (creatine phosphokinase (CK), 3038 IU/l). He was diagnosed as malignant catatonia. Intravenous administration of acyclovir, high-dose methylprednisolone, antibiotics, diazepam, and dantrolene sodium was not effective. After initiating oral administration of olanzapine, his condition improved.
我们报告了一例29岁男性病例，该患者无法记住一些汉字词汇并表现出情绪不稳定。其脑部磁共振成像（MRI）扫描显示正常。脑脊液（CSF）分析显示淋巴细胞增多。脑电图（EEG）显示大脑双侧额叶区域有慢波活动。他被诊断为急性脑炎。在住院的第四天，他被发现呈紧张症状态，表现为缄默、运动不能和僵住症。在第九天，他出现高热、肌肉强直、吞咽困难、呼吸功能不全和横纹肌溶解（肌酸磷酸激酶（CK），3038 IU/L）。他被诊断为恶性紧张症。静脉注射阿昔洛韦、大剂量甲基强的松龙、抗生素、地西泮和丹曲林钠均无效。在开始口服奥氮平后，他的病情有所改善。
