Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy.
Ann N Y Acad Sci. 2010 Apr;1194:6-19. doi: 10.1111/j.1749-6632.2010.05484.x.
Thymosin alpha-1 (Talpha1) is a molecule retaining pleiotropic effects toward several pathological conditions, especially acting as a modulator of immune response and inflammation. However, molecular mechanisms underlying the peculiar, wide-range activity of Talpha1 have not been completely elucidated. To get information on the mechanism of action of Talpha1 and to find new potential applications, we performed the analysis of the transcription profile of 8300 genes in human peripheral blood mononuclear cells in vitro treated with Talpha1. Together with a variety of genes already known to be modulated by Talpha1, our analysis revealed a remarkable number of genes not yet described before to be modulated by this thymic peptide, revealing a complex scenario that underlines the role of this peptide as a regulator of lymphocyte functions. Here, we report the list of the more representative modulated genes and discuss their implications on the modulation of the innate and adaptive responses. Our results open new perspectives on the use of Talpha1 for the treatment of diseases associated with immune-disregulation.
胸腺肽α1（Talpha1）是一种具有多种病理作用的多功能分子，尤其作为免疫反应和炎症的调节剂。然而，Talpha1 奇特的广谱活性的分子机制尚未完全阐明。为了获得 Talpha1 作用机制的信息并寻找新的潜在应用，我们对体外用 Talpha1 处理的人外周血单个核细胞的 8300 个基因的转录谱进行了分析。除了已经知道的多种受 Talpha1 调节的基因外，我们的分析还揭示了大量以前尚未描述的受这种胸腺肽调节的基因，揭示了一个复杂的情况，强调了这种肽作为淋巴细胞功能调节剂的作用。在这里，我们报告了更具代表性的调节基因列表，并讨论了它们对先天和适应性反应调节的影响。我们的结果为 Talpha1 治疗与免疫失调相关的疾病开辟了新的前景。
