香草酸和瞬时受体电位通道在血管平滑肌中的作用。
Vanilloid and melastatin transient receptor potential channels in vascular smooth muscle.
机构信息
Vascular Physiology Research Group, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
出版信息
Microcirculation. 2010 May;17(4):237-49. doi: 10.1111/j.1549-8719.2010.00026.x.
Abstract
The mammalian transient receptor potential (TRP) superfamily consists of six subfamilies that are defined by structural homology: TRPC (conventional or canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPP (polycystin), and TRPML (mucoliptin). This review focuses on channels belonging to the vanilloid (V) and melastatin (M) TRP subfamilies. The TRPV subfamily consists of six members (TRPV1-6) and the TRPM subfamily has eight (TRPM1-8). The basic biophysical properties of these channels are briefly described. All of these channels except TRPV5, TRPV6, and TRPM1 are reportedly present in arterial smooth muscle from various segments of the vasculature. Studies demonstrating involvement of TRPV1, TRPV2, TRPV4, TRPM4, TRPM7, and TRPM8 in regulation of arterial smooth muscle function are reviewed. The functions of TRPV3, TRPM2, TRPM3, and TRPM6 channels in arterial myocytes have not been reported.
摘要
哺乳动物瞬时受体电位（TRP）超家族由六个亚家族组成，这些亚家族通过结构同源性来定义：TRPC（常规或经典）、TRPV（香草素）、TRPM（melastatin）、TRPA（ankyrin）、TRPP（polycystin）和 TRPML（mucoliptin）。本篇综述聚焦于属于香草素（V）和 melastatin（M）TRP 亚家族的通道。TRPV 亚家族由六个成员（TRPV1-6）组成，而 TRPM 亚家族有八个（TRPM1-8）。这些通道的基本生物物理特性简要描述如下。除了 TRPV5、TRPV6 和 TRPM1，据报道这些通道均存在于血管不同节段的动脉平滑肌中。本文综述了 TRPV1、TRPV2、TRPV4、TRPM4、TRPM7 和 TRPM8 在调节动脉平滑肌功能中的作用。TRPV3、TRPM2、TRPM3 和 TRPM6 通道在动脉肌细胞中的功能尚未报道。
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