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香橼精油可减轻表皮角质形成细胞中与酒渣鼻病理生理学相关的介质。

Citron Essential Oils Alleviate the Mediators Related to Rosacea Pathophysiology in Epidermal Keratinocytes.

作者信息

Jeon Hyeon Woo, Na Eui Young, Yun Sook Jung, Lee Seung-Chul, Lee Jee-Bum

机构信息

Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.

出版信息

Ann Dermatol. 2018 Dec;30(6):653-661. doi: 10.5021/ad.2018.30.6.653. Epub 2018 Oct 26.

DOI:10.5021/ad.2018.30.6.653
PMID:33911504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7992447/
Abstract

BACKGROUND

Citron is well known for an abundance of antioxidative and anti-inflammatory ingredients such as vitamin C, polyphenol compounds, flavonoids, and limonoids.

OBJECTIVE

In this study, we aimed to evaluate the effects of citron essential oils on rosacea mediators in activated keratinocytes .

METHODS

Normal human epidermal keratinocytes (NHEKs) were stimulated with 1α, 25-dihydroxyvitamin D (VD) and interleukin 33 (IL-33) with LL-37 to induce rosacea mediators such as kallikrein 5 (KLK5), cathelicidin, vascular endothelial growth factor (VEGF), and transient receptor potential vanilloid 1 (TRPV1). These mediators were analyzed by performing reverse-transcription polymerase chain reaction (PCR), quantitative real-time PCR, immunocytofluorescence and enzyme-linked immunosorbent assay after NHEKs were treated with citron seed and unripe citron essential oils.

RESULTS

The messenger RNA (mRNA) and protein levels of KLK5 and LL-37 induced by VD were suppressed by citron seed and unripe citron essential oils. Furthermore, the mRNA and protein levels of VEGF and TRPV1 induced by IL-33 with LL-37 were also suppressed by citron essential oils.

CONCLUSION

These results show that citron essential oils have suppressive effects on rosacea mediators in activated epidermal keratinocytes, which indicates that the citron essential oils may be valuable adjuvant therapeutic agents for rosacea.

摘要

背景

香橼以富含抗氧化和抗炎成分而闻名，如维生素C、多酚化合物、黄酮类化合物和柠檬苦素类化合物。

目的

在本研究中，我们旨在评估香橼精油对活化角质形成细胞中酒渣鼻介质的影响。

方法

用1α,25 - 二羟基维生素D（VD）、白细胞介素33（IL - 33）和LL - 37刺激正常人表皮角质形成细胞（NHEKs），以诱导酒渣鼻介质，如激肽释放酶5（KLK5）、杀菌肽、血管内皮生长因子（VEGF）和瞬时受体电位香草酸亚型1（TRPV1）。在用香橼籽精油和未成熟香橼精油处理NHEKs后，通过逆转录聚合酶链反应（PCR）、定量实时PCR、免疫细胞荧光和酶联免疫吸附测定法分析这些介质。

结果

香橼籽精油和未成熟香橼精油抑制了VD诱导的KLK5和LL - 37的信使核糖核酸（mRNA）和蛋白质水平。此外，香橼精油也抑制了IL - 33与LL - 37诱导的VEGF和TRPV1的mRNA和蛋白质水平。

结论

这些结果表明，香橼精油对活化的表皮角质形成细胞中的酒渣鼻介质具有抑制作用，这表明香橼精油可能是酒渣鼻有价值的辅助治疗剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44fe/7992447/52dd538f2f82/ad-30-653-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44fe/7992447/4fe52a932899/ad-30-653-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44fe/7992447/6676023a9ef7/ad-30-653-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44fe/7992447/52dd538f2f82/ad-30-653-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44fe/7992447/4fe52a932899/ad-30-653-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44fe/7992447/6676023a9ef7/ad-30-653-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44fe/7992447/52dd538f2f82/ad-30-653-g003.jpg

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