Department of Otorhinolaryngology-Head and Neck Surgery, Masan Samsung Hospital, Masan, Korea.
Am J Rhinol Allergy. 2010 May-Jun;24(3):226-9. doi: 10.2500/ajra.2010.24.3459.
When the skin-prick test (SPT) and in vitro test such as ImmunoCAP assay are performed simultaneously, results do not always coincide in some patients. Our objectives, therefore, were (1) to assess differences in allergic test results according to age group and (2) to establish appropriate guidelines for diagnosing mite allergy according to age.
A total of 692 participants complaining of allergic rhinitis symptoms participated. Patients were divided according to age; the mean age was 32 years (range, 8-76 years). The SPT and ImmunoCAP assays were performed to detect allergies to house-dust mites (Dermatophagoides pteronyssinus and Dermatophagoides farinae). The association between age and the result of each allergy test were examined, and a cutoff age for proper application of each test was than estimated.
Three hundred thirty-six patients (48.6%) were allergic to D. pteronyssinus and 350 patients (50.6%) were allergic to D. farinae. In the case of D. pteronyssinus, SPT was proved to be more useful in detecting allergy for subjects <50 years old (p < 0.0001). However in case of D. farinae, ImmunoCAP was useful for all age groups, but SPT showed decreased ratio of positive result for subjects >30 years old (p < 0.0001).
This study was the first to compare results of allergy tests according to age using true allergens. For patients >50 years of age, the ImmunoCAP was found to be the preferred method for detecting allergy to house-dust mites and for patients <30 years old, SPT is the recommended first choice.
当进行皮肤点刺试验（SPT）和体外试验（如 ImmunoCAP 检测）时，在某些患者中，结果并不总是一致的。因此，我们的目的是：（1）评估根据年龄组的过敏测试结果差异；（2）根据年龄制定诊断尘螨过敏的适当指南。
共有 692 名患有过敏性鼻炎症状的患者参加。根据年龄将患者分为：平均年龄 32 岁（范围：8-76 岁）。进行 SPT 和 ImmunoCAP 检测以检测对屋尘螨（屋尘螨和粉尘螨）的过敏。检查年龄与每种过敏测试结果之间的关联，并估计每个测试的适当应用的截止年龄。
336 名患者（48.6%）对 D. pteronyssinus 过敏，350 名患者（50.6%）对 D. farinae 过敏。在 D. pteronyssinus 的情况下，SPT 被证明更适用于检测 <50 岁的患者的过敏（p < 0.0001）。然而，在 D. farinae 的情况下，ImmunoCAP 对所有年龄组均有用，但 SPT 显示出年龄> 30 岁的患者阳性结果的比例降低（p < 0.0001）。
这项研究首次使用真实过敏原比较了根据年龄的过敏测试结果。对于>50 岁的患者，ImmunoCAP 被发现是检测屋尘螨过敏的首选方法，对于<30 岁的患者，SPT 是首选方法。
