Department of Neurology, Univ. of Iowa, Iowa City, IA 52242, USA.
Auton Neurosci. 2010 Aug 25;156(1-2):152-3. doi: 10.1016/j.autneu.2010.04.012.
A dense network of nerves containing neuronal nitric oxide synthase is present in cerebral vessels from experimental animals. The nerves may regulate cerebrovascular tone, protect the brain from stroke, and contribute to cluster headaches in humans; but studies in humans have shown only modest nitroxidergic innervation of cerebral vessels. We tested the hypothesis that nerve fibers containing neuronal nitric oxide synthase richly innervate human cerebral arteries. We used immunohistochemical techniques at post mortem and found dense neuronal nitric oxide synthase nerve staining in human cerebral vessel walls consistent with participation of nitroxidergic fibers in human physiological and pathophysiological processes.
在实验动物的脑血管中存在着富含神经元型一氧化氮合酶的密集神经网络。这些神经可能调节脑血管张力、保护大脑免受中风的影响，并导致人类偏头痛发作；但人体研究仅显示出脑内血管的适度一氧化氮合酶能神经支配。我们检验了这样一个假说，即富含神经元型一氧化氮合酶的神经纤维大量支配着人类大脑动脉。我们使用死后免疫组织化学技术，在人类脑血管壁中发现了密集的神经元型一氧化氮合酶神经染色，这表明一氧化氮合酶能神经纤维参与了人类的生理和病理生理过程。
