Minami Y, Kimura H, Aimi Y, Vincent S R
Department of Surgery, Shiga University of Medical Science, Otsu, Japan.
Neuroscience. 1994 Jun;60(3):745-59. doi: 10.1016/0306-4522(94)90502-9.
The origin and distribution of cerebral perivascular nerves containing nitric oxide, a short-acting messenger or neurotransmitter, have been studied in the rat by histochemistry for reduced nicotinamide adenine dinucleotide phosphate-diaphorase activity, a specific marker for neuronal nitric oxide synthase. Positively stained nerve fibers were distributed throughout the major vessels of the cerebral arteries, though the fiber density was higher in the anterior circulation, including the circle of Willis, than in the posterior arteries. Examination using axonal transport methods indicated that nitric oxide-containing neurons in the sphenopalatine ganglion innervate the cerebral arteries bilaterally. Nitric oxide synthase in these ganglionic cells often co-existed with vasoactive intestinal polypeptide. The anatomical information obtained is discussed in terms of non-adrenergic, non-cholinergic neuronal transmission in the cerebral arteries.
通过对还原型烟酰胺腺嘌呤二核苷酸磷酸黄递酶活性进行组织化学研究，一种神经元型一氧化氮合酶的特异性标记物，在大鼠中研究了含一氧化氮（一种短效信使或神经递质）的脑周血管神经的起源和分布。阳性染色的神经纤维分布于脑动脉的主要血管周围，尽管在前循环（包括 Willis 环）中的纤维密度高于后循环动脉。使用轴突运输方法的检查表明，蝶腭神经节中含一氧化氮的神经元双侧支配脑动脉。这些神经节细胞中的一氧化氮合酶常与血管活性肠肽共存。根据脑动脉中非肾上腺素能、非胆碱能神经元传递对所获得的解剖学信息进行了讨论。
