Berghmans T
Department of Internal Medicine, Institut Jules Bordet, Brussels, Belgium.
Support Care Cancer. 1996 Sep;4(5):341-50. doi: 10.1007/BF01788840.
Hyponatremia is a common potential complication in cancer patients. It can be related to anticancer medical therapy. Vincristine, vinblastine, cisplatin and cyclophosphamide are the chemotherapeutic agents most frequently associated with hyponatremia. More recently, analogs such as carboplatin and ifosfamide have also been incriminated. Hyponatremia is also associated with new immunomodulators (interferon, interleukin-2 and levamisole) and monoclonal antibodies. The mechanism by which all these drugs act on the sodium steady state is only partially known. The syndrome of inappropriate antidiuretic hormone secretion is described secondary to vinca alkaloids and cisplatin and possibly with alkylating agents. Renal salt wasting is described with platinum compounds.
低钠血症是癌症患者常见的潜在并发症。它可能与抗癌药物治疗有关。长春新碱、长春碱、顺铂和环磷酰胺是最常与低钠血症相关的化疗药物。最近，卡铂和异环磷酰胺等类似物也被认为与此有关。低钠血症还与新型免疫调节剂（干扰素、白细胞介素-2和左旋咪唑）及单克隆抗体有关。所有这些药物作用于钠稳态的机制仅部分为人所知。抗利尿激素分泌不当综合征继发于长春花生物碱和顺铂，可能也与烷化剂有关。铂类化合物可导致肾性盐耗竭。
