Department of Psychiatry and Behavioral Neurosciences, Wayne State University, School of Medicine, 2751 E. Jefferson, Detroit, MI 48207 USA.
Schizophr Res. 2010 Aug;121(1-3):139-45. doi: 10.1016/j.schres.2010.04.020. Epub 2010 May 26.
The interrelationship between the ability to inhibit incoming redundant input (gating out) and the ability of the brain to respond when the stimulus changes (gating in), has not been extensively examined. We administered a battery of auditory evoked potential tests to a group of chronic, medicated schizophrenia patients (N=12) and a group of healthy subjects (N=12) in order to examine relationships between "gating out" measures (suppression with repetition of the P50, N100, and P200 evoked responses), and the mismatch negativity (MMN) and the P300 event related potentials as measures of "gating in". Gating ratios for N100 and P200 in a visual attention paired-click task differed significantly between groups. Mismatch negativity and P300 potential amplitudes were also significantly reduced in the patient group. When including all subjects (N=24) a negative correlation was found between the P50 gating and the amplitude of the MMN. In healthy subjects this correlation was significantly stronger compared to schizophrenia patients. While no significant correlation was noted between the amplitudes of the P300 and any gating measures when all 24 subjects were included, a significant negative correlation was seen between the P200 gating and the P300 amplitudes in schizophrenia patients; an opposite trend was noted in healthy subjects. Finally, a positive correlation was seen between the P300 and MMN (to abstract deviance) amplitudes in healthy subjects, but the opposite was found in patients. These results suggest that further study of these interrelationships could inform the understanding of information processing abnormalities in schizophrenia.
我们对一组慢性、用药的精神分裂症患者（N=12）和一组健康受试者（N=12）进行了一系列听觉诱发电位测试，以检查“门控输出”测量值（抑制重复的 P50、N100 和 P200 诱发电反应）与失匹配负波（MMN）和 P300 事件相关电位之间的关系，作为“门控输入”的测量值。在视觉注意对点击任务中，N100 和 P200 的门控比值在两组之间有显著差异。患者组的失匹配负波和 P300 电位幅度也明显降低。当包括所有受试者（N=24）时，发现 P50 门控与 MMN 幅度之间存在负相关。在健康受试者中，与精神分裂症患者相比，这种相关性明显更强。当包括所有 24 名受试者时，未注意到 P300 幅度与任何门控测量值之间存在显著相关性，但在精神分裂症患者中观察到 P200 门控与 P300 幅度之间存在显著负相关；在健康受试者中则观察到相反的趋势。最后，在健康受试者中观察到 P300 与 MMN（抽象偏差）幅度之间存在正相关，但在患者中则相反。这些结果表明，进一步研究这些相互关系可能有助于了解精神分裂症中的信息处理异常。
