Laurent S, Safar M
Laboratoires d'hémodynamique de l'hypertension artérielle, hôpital Broussais, Paris.
Arch Mal Coeur Vaiss. 1991 Jan;84 Spec No 1:59-63.
Hypertension has long been considered to be a disease of the arterioles but it also concerns the great arteries. The hypothesis for this study was that the antihypertensive agents used in the large multicenter trials only partially correct the hemodynamic abnormalities of hypertension. The regression of the structural arterial changes responsible for the decreased arterial compliance, the regression of left ventricular hypertrophy without alteration of systolic function, the decrease in the variability of the blood pressure and the maintenance of regional blood flow should also be considered as therapeutic objectives for vasodilator antihypertensive therapy.
长期以来，高血压一直被认为是小动脉疾病，但它也与大动脉有关。本研究的假设是，大型多中心试验中使用的抗高血压药物仅部分纠正了高血压的血流动力学异常。负责降低动脉顺应性的动脉结构变化的消退、左心室肥厚的消退而不改变收缩功能、血压变异性的降低以及局部血流的维持也应被视为血管扩张剂抗高血压治疗的治疗目标。
