Department of Molecular Biology, Institute of Parasitology, Polish Academy of Sciences, Warsaw, Poland.
Vet Parasitol. 2010 Sep 20;172(3-4):229-37. doi: 10.1016/j.vetpar.2010.05.008. Epub 2010 May 16.
Fasciola hepatica infections cause huge economic losses to livestock production and are a serious problem in human and veterinary medicine. The main difficulty in the control of infections is progressing drug resistance. Moreover, pharmacological therapy is expensive and harmful for the environment. The best way of prophylaxis against infections seems to be vaccination. A new generation of vaccines could be the best possible way of controlling fasciolosis. This paper is focused on first vaccination trials based on a new vaccine candidate antigen, F. hepatica phosphoglycerate kinase (FhPGK) performed on a rat model. We obtained protection levels ranging from 0% to 69% depending on the way of delivery and form of vaccine.
肝片形吸虫感染给畜牧业生产造成了巨大的经济损失，也是人类和兽医医学中的一个严重问题。感染控制的主要困难是耐药性的进展。此外，药理学治疗既昂贵又对环境有害。预防感染的最佳方法似乎是接种疫苗。新一代疫苗可能是控制片形吸虫病的最佳方法。本文重点介绍了在大鼠模型上进行的基于新型疫苗候选抗原肝片形吸虫磷酸甘油酸激酶（FhPGK）的首次疫苗接种试验。我们根据递送方式和疫苗形式获得了 0%至 69%的保护水平。
