Department of General Practice, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, The Netherlands.
Respir Med. 2010 Nov;104(11):1675-82. doi: 10.1016/j.rmed.2010.04.023. Epub 2010 Jun 11.
Questionnaires are often used in assessing health-related quality of life in patients with chronic obstructive pulmonary disease (COPD). It is important that these questionnaires have good reliability, validity, and responsiveness. The aim of this study was to investigate and compare these properties in the disease specific Clinical COPD Questionnaire (CCQ) and the Chronic Respiratory Questionnaire self-reported (CRQ-SR).
Two hundred ninety six participants with spirometry confirmed mild to moderate COPD were included in a smoking cessation trial. It was assumed that health-related quality of life would improve in participants who stopped smoking. The questionnaires were administered at baseline and at weeks 5, 26, and 52 after the target quit date.
At baseline, 292 (97%) participants returned the CCQ and 296 (100%) the CRQ-SR questionnaire. For both instruments, the internal consistency was good (Cronbach's alpha >70%) as was the convergent validity with each other but not with spirometry. The CCQ was responsive to improvements in respiratory symptoms at both week 26 (-1.02, SD = 0.81) and 52 (-1.04, SD = 0.91) and in the total score at week 26 (-0.54, SD = 0.50) and 52 (-0.43, SD = 0.44). The mastery domain and the total score of the CRQ-SR were responsive at week 26 (1.14, SD = 0.82; 0.67, SD = 0.97 respectively) but not at week 52 (0.04, SD = 0.93; 0.38, SD = 0.57 respectively).
Both the CCQ and CRQ-SR are equally reliable and valid. The long-term responsiveness of the CCQ is better. Both questionnaires can be used in future studies involving patients with mild to moderate COPD. However, when the follow-up exceeds 26 weeks, the CCQ is the recommended alternative. Netherlands Trial Register: ISRCTN 64481813.
问卷常用于评估慢性阻塞性肺疾病（COPD）患者的健康相关生活质量。这些问卷具有良好的可靠性、有效性和反应性非常重要。本研究旨在研究和比较特定于疾病的临床 COPD 问卷（CCQ）和慢性呼吸问卷自我报告（CRQ-SR）的这些特性。
296 名接受过肺活量计确认的轻度至中度 COPD 的参与者被纳入一项戒烟试验。假设戒烟的参与者的健康相关生活质量会提高。问卷在目标戒烟日期后 5 周、26 周和 52 周进行。
在基线时，292 名（97%）参与者返回了 CCQ，296 名（100%）参与者返回了 CRQ-SR 问卷。对于这两种工具，内部一致性都很好（Cronbach's alpha >70%），与彼此的收敛有效性也很好，但与肺活量计无关。CCQ 在第 26 周（-1.02，SD=0.81）和第 52 周（-1.04，SD=0.91）时对呼吸症状的改善以及第 26 周（-0.54，SD=0.50）和第 52 周（-0.43，SD=0.44）时的总分均具有反应性。CRQ-SR 的掌握领域和总分在第 26 周时具有反应性（分别为 1.14，SD=0.82；0.67，SD=0.97），但在第 52 周时没有反应性（分别为 0.04，SD=0.93；0.38，SD=0.57）。
CCQ 和 CRQ-SR 同样可靠且有效。CCQ 的长期反应性更好。两种问卷都可用于涉及轻度至中度 COPD 患者的未来研究。然而，当随访时间超过 26 周时，CCQ 是首选。荷兰试验注册处：ISRCTN64481813。
