Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Bioorg Med Chem Lett. 2010 Jul 15;20(14):4108-11. doi: 10.1016/j.bmcl.2010.05.073. Epub 2010 Jun 9.
Synthesis of the marine natural products motualevic acids A, E, and analogs in which modifications have been made to the omega-brominated lipid (E)-14,14-dibromotetra-deca-2,13-dienoic acid or amino acid unit are reported, together with antimicrobial activities against Staphylococcus aureus, methicillin-resistant S. aureus, Enterococcus faecium, and vancomycin-resistant Enterococcus.
报道了海洋天然产物莫特乌列维酸 A、E 及其类似物的合成，这些类似物对ω-溴化脂质（E）-14,14-二溴十四碳-2,13-二烯酸或氨基酸单元进行了修饰，同时还具有抗金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌、屎肠球菌和万古霉素耐药肠球菌的抗菌活性。
