Levy Stuart B, Marshall Bonnie
Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
Nat Med. 2004 Dec;10(12 Suppl):S122-9. doi: 10.1038/nm1145.
The optimism of the early period of antimicrobial discovery has been tempered by the emergence of bacterial strains with resistance to these therapeutics. Today, clinically important bacteria are characterized not only by single drug resistance but also by multiple antibiotic resistance--the legacy of past decades of antimicrobial use and misuse. Drug resistance presents an ever-increasing global public health threat that involves all major microbial pathogens and antimicrobial drugs.
抗菌药物发现早期的乐观情绪因对这些治疗药物产生耐药性的细菌菌株的出现而有所缓和。如今，具有临床重要性的细菌不仅表现出对单一药物的耐药性，还表现出多重耐药性——这是过去几十年抗菌药物使用和滥用的遗留问题。耐药性对全球公共卫生构成了日益严重的威胁，涉及所有主要的微生物病原体和抗菌药物。
