用于生产治疗性放射性核素193mPt的α粒子与192Os发生的反应截面的放射化学测定。
Radiochemical determination of cross sections of alpha-particle induced reactions on 192Os for the production of the therapeutic radionuclide 193mPt.
作者信息
Uddin M S, Scholten B, Hermanne A, Sudár S, Coenen H H, Qaim S M
机构信息
Institut für Neurowissenschaften und Medizin, INM-5, Nuklearchemie, Forschungszentrum Jülich, D-52425 Jülich, Germany.
出版信息
Appl Radiat Isot. 2010 Oct;68(10):2001-6. doi: 10.1016/j.apradiso.2010.05.002. Epub 2010 May 12.
For determination of cross sections of alpha-particle induced reactions on 99.65% enriched (192)Os, the methods for electrolytic preparation of thin samples and radiochemical separation of radioplatinum were optimized. The excitation functions of the (192)Os(alpha,n)(195m)Pt and (192)Os(alpha,3n) (193m)Pt reactions were measured from 20 to 39 MeV. The cross section of the latter reaction reaches a maximum value of about 1.5b at an energy around 36 MeV. The results of nuclear model calculations using the codes TALYS and STAPRE agreed well with the measured data. The optimum energy range for the production of no-carrier-added (193m)Pt (T(1/2)=4.33 d) was found to be E(alpha)=40-->30 MeV. The thick target yield amounts to 10 MBq/microA h and a possible batch yield of 2 GBq should be sufficient for Auger electron therapy on a wide scale.
为了测定α粒子与99.65%富集的¹⁹²Os发生反应的截面，对电解制备薄样品和放射性铂的放射化学分离方法进行了优化。测量了¹⁹²Os(α,n)¹⁹⁵mPt和¹⁹²Os(α,3n)¹⁹³mPt反应在20至39 MeV能量范围内的激发函数。后一个反应的截面在约36 MeV能量处达到最大值，约为1.5靶恩。使用TALYS和STAPRE程序进行的核模型计算结果与测量数据吻合良好。发现无载体添加¹⁹³mPt（半衰期T(1/2)=4.33天）生产的最佳能量范围为E(α)=40→30 MeV。厚靶产额为10 MBq/μA h，2 GBq的可能批量产额应足以广泛用于俄歇电子治疗。
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