使用 MetaCore 图谱对 Endeavour 进行大规模基准测试。
Large-scale benchmark of Endeavour using MetaCore maps.
机构信息
Novartis Pharma AG, Postfach, Basel, Switzerland.
出版信息
Bioinformatics. 2010 Aug 1;26(15):1922-3. doi: 10.1093/bioinformatics/btq307. Epub 2010 Jun 10.
SUMMARY
Endeavour is a tool that detects the most promising genes within large lists of candidates with respect to a biological process of interest and by combining several genomic data sources. We have benchmarked Endeavour using 450 pathway maps and 826 disease marker sets from MetaCore of GeneGo, Inc. containing a total of 9911 and 12 432 genes, respectively. We obtained an area under the receiver operating characteristic curves of 0.97 for pathway and of 0.91 for disease gene sets. These results indicate that Endeavour can be used to efficiently prioritize candidate genes for pathways and diseases.
AVAILABILITY
Endeavour is available at http://www.esat.kuleuven.be/endeavour
摘要
Endeavour 是一款工具，可针对感兴趣的生物过程，通过整合多个基因组数据源，从大量候选基因中筛选出最有前途的基因。我们使用 450 条途径图谱和来自 GeneGo 公司的 MetaCore 的 826 个疾病标志物集对 Endeavour 进行了基准测试，这些图谱和标志物集分别包含了 9911 个和 12432 个基因。我们得到的途径和疾病基因集的接收器操作特性曲线下面积分别为 0.97 和 0.91。这些结果表明，Endeavour 可用于有效地确定途径和疾病的候选基因的优先级。
可用性
Endeavour 可在 http://www.esat.kuleuven.be/endeavour 上获得。
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