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从.根茎中分离得到的新甾体皂苷

New Steroidal Saponins Isolated from the Rhizomes of .

机构信息

Department of Pharmaceutics, School of Pharmacy, Air Force Medical University, Xi'an 710032, China.

Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi'an 710032, China.

出版信息

Molecules. 2021 Oct 21;26(21):6366. doi: 10.3390/molecules26216366.

DOI:10.3390/molecules26216366
PMID:34770773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8588014/
Abstract

The genus is an excellent source of steroidal saponins that exhibit various bioactivities. is a unique species and has been widely used as folk medicine in Southwest China for a long time. With the help of chemical methods and modern spectra analysis, five new steroidal saponins, pamaiosides A-E (-), along with five known steroidal saponins -, were isolated from the rhizomes of . The cytotoxicity of all the new saponins was evaluated against human pancreatic adenocarcinoma PANC-1 and BxPC3 cell lines.

摘要

是一个甾体皂苷的重要来源，具有多种生物活性。 是一个独特的物种，长期以来一直被广泛用作中国西南地区的民间药物。在化学方法和现代光谱分析的帮助下，从 的根茎中分离得到了五种新的甾体皂苷 pamaiosides A-E (-)，以及五种已知的甾体皂苷 。所有新皂苷的细胞毒性都针对人胰腺腺癌细胞系 PANC-1 和 BxPC3 进行了评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0144/8588014/89503327ca8d/molecules-26-06366-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0144/8588014/17d89bf09de2/molecules-26-06366-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0144/8588014/4a941efba3d8/molecules-26-06366-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0144/8588014/fb82d98f5240/molecules-26-06366-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0144/8588014/3230af99bf77/molecules-26-06366-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0144/8588014/e2c5f0ff24f7/molecules-26-06366-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0144/8588014/89503327ca8d/molecules-26-06366-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0144/8588014/17d89bf09de2/molecules-26-06366-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0144/8588014/4a941efba3d8/molecules-26-06366-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0144/8588014/fb82d98f5240/molecules-26-06366-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0144/8588014/3230af99bf77/molecules-26-06366-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0144/8588014/e2c5f0ff24f7/molecules-26-06366-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0144/8588014/89503327ca8d/molecules-26-06366-g006.jpg

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