壳聚糖可以阻止或延缓口蹄疫病毒攻击的乳鼠死亡。
Chitosan can stop or postpone the death of the suckling mice challenged with foot-and-mouth disease virus.
机构信息
Key laboratory of Animal Virology of Ministry of Agriculture, National Foot-and-Mouth Disease Reference Laboratory of China, State Key Laboratory of Veterinary Etiologic Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, 730046, China.
出版信息
Virol J. 2010 Jun 12;7:125. doi: 10.1186/1743-422X-7-125.
UNLABELLED
In the study, a method called "hardening in liquid phase" for preparing chitosan granules with glutaraldehyde as crosslinker and Tween 80 as surfactant and paraffin liquid as dispersant was established. The chitosan granules were light yellow and insoluble in water or oil, but they swelled in acid solution and narrowed in neutral or alkaline solution. Furthermore, some of characteristics of the chitosan granules were revealed. (a) Stability: Their shapes were stable at pH 7.0 and pH 8.0 and -30 degrees C-120 degrees C. The shelf life is at least one year in vitro at room temperature. (b)
SAFETY
Some experiments of their lethal effect to suckling mice and pathogenicity to mature mice proved the chitosan granules were harmless. (c) Antiviral activity: Some suckling mice injected with chitosan granules were still alive or delayed death compared with control group when they challenged with foot-and-mouth disease virus (FMDV). Such anti-FMDV capacity could maintain 1 week and was the strongest on the third day.
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在研究中，建立了一种使用戊二醛作为交联剂、吐温 80 作为表面活性剂、石蜡液体作为分散剂制备壳聚糖颗粒的“液相硬化”方法。壳聚糖颗粒呈浅黄色，不溶于水或油，但在酸性溶液中会膨胀，在中性或碱性溶液中会缩小。此外，还揭示了壳聚糖颗粒的一些特性。（a）稳定性：在 pH 值为 7.0 和 pH 值为 8.0 以及-30°C-120°C 的条件下，其形状稳定。在室温下，体外至少可保存一年。（b）安全性：一些关于其对幼鼠致死作用和对成熟鼠致病性的实验证明壳聚糖颗粒是无害的。（c）抗病毒活性：一些注射壳聚糖颗粒的幼鼠在口蹄疫病毒（FMDV）攻击时与对照组相比仍然存活或延迟死亡。这种抗 FMDV 能力可维持 1 周，第 3 天最强。
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