State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, China.
State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, China.
Mol Immunol. 2019 Oct;114:226-232. doi: 10.1016/j.molimm.2019.07.021. Epub 2019 Aug 3.
Foot and mouth disease virus (FMDV), a member of family Picornaviridae, belongs to the genus Aphthovirus, which causes foot and mouth disease (FMD), a highly transmissible disease that affects cloven-hoof animals. In spite of the fact that efficient vaccines are available, effective antiviral molecules for FMD are needed to reduce viral infection during early stages of infection. In this study, merimepodib was found to efficiently inhibit FMDV replication in a dose-dependent manner. The 50% inhibitory concentration (IC) of merimepodib antiviral activity against two distinct FMDV strains (O/MYA98/BY/2010 and A/GD/MM/CHA/2013) was estimated to be 7.859 and 2.876 μM, respectively, while the 50% cytotoxic concentration (CC) of merimepodib was found to be 47.74 μM. Furthermore, treatment with 30 μg merimepodib efficiently prolonged the survival time of suckling mice infected with FMDV. Taken together, these results suggested that merimepodib has the potential to be a novel antiviral agent against FMDV.
口蹄疫病毒（FMDV）是小 RNA 病毒科的成员，属于口疮病毒属，可引起口蹄疫（FMD），这是一种高度传染性疾病，可影响偶蹄动物。尽管有有效的疫苗，但仍需要有效的抗病毒分子来减少感染早期的病毒感染。在这项研究中，发现梅里莫波迪布能够以剂量依赖的方式有效抑制 FMDV 的复制。梅里莫波迪布抗两种不同 FMDV 株（O/MYA98/BY/2010 和 A/GD/MM/CHA/2013）的抗病毒活性的 50%抑制浓度（IC）分别估计为 7.859 和 2.876 μM，而梅里莫波迪布的 50%细胞毒性浓度（CC）为 47.74 μM。此外，用 30μg 梅里莫波迪布治疗可有效延长感染 FMDV 的乳鼠的存活时间。综上所述，这些结果表明梅里莫波迪布有可能成为一种新型抗 FMDV 的抗病毒药物。
