College of Engineering and Mathematical Sciences, University of Vermont, Burlington, VT 05405, USA.
Eur Spine J. 2010 Dec;19(12):2110-6. doi: 10.1007/s00586-010-1473-z. Epub 2010 Jun 11.
Needle puncture is a common method of inducing intervertebral disc (IVD) degeneration in small animal models and may have some similarities to IVD injury conditions such as herniation. Yet, the influence of puncture injuries on IVD biomechanics is not well understood. This study quantified the acute effects of anular injury on the biomechanics of rat caudal IVDs in compression and torsion following puncture with 30, 25 and 21 G needles. In compression, puncture injury reduced elastic stiffness by 20% for all needle sizes, but differences between control and punctured discs did not remain after compressive overload. In contrast, torsional parameters associated with anular fiber tension were affected proportionally with needle size. We conclude that IVD injuries that penetrate through the thickness of the annulus affect IVD biomechanics through different mechanisms for compression and torsion. Anular injuries affect torsional properties in a manner directly related to the amount of fiber disruption and compressive properties in a manner that affects pressurization.
针刺是一种诱导小动物椎间盘（IVD）退变的常用方法，可能与椎间盘突出等 IVD 损伤情况有一些相似之处。然而，针刺损伤对 IVD 生物力学的影响尚不清楚。本研究量化了 30G、25G 和 21G 针穿刺对大鼠尾部 IVD 在压缩和扭转时生物力学的急性影响。在压缩状态下，所有针型的针刺损伤都会使弹性刚度降低 20%，但在压缩过载后，对照组和针刺组之间的差异不再存在。相比之下，与环状纤维张力相关的扭转参数与针型成比例地受到影响。我们得出结论，穿透环厚度的 IVD 损伤通过不同的机制影响压缩和扭转时的 IVD 生物力学。环状损伤以与纤维破坏量直接相关的方式影响扭转特性，以影响加压的方式影响压缩特性。
