Department of Hematology Oncology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Qual Life Res. 2010 Nov;19(9):1243-54. doi: 10.1007/s11136-010-9688-3. Epub 2010 Jun 11.
To evaluate quality of life (QoL) in patients with head and neck squamous cell carcinoma (HNSCC) treated by combined modality therapy, with a focus on the therapeutic benefits of QoL that result from technological advances in radiotherapy (RT).
A cross-sectional survey of QoL using the EORTC QLQ-C30 and QLQ-H&N35 questionnaires was performed for 307 HNSCC survivors. One hundred and thirty-five patients were treated by two-dimensional RT (2DRT), 90 by three-dimensional conformal RT (3DCRT), and 82 by intensity-modulated RT (IMRT). The effect size between groups was calculated using Cohen's D coefficient.
Those who had a higher annual family income or were treated by more advanced RT techniques had better QoL outcomes. Compared with 2DRT, the impact of 3DCRT was small (Cohen's D: 0.02-0.40) on all QoL scales. For IMRT, the impact was small on most scales and moderate (Cohen's D: 0.55-0.60) on opening mouth, dry mouth, and sticky saliva. Compared with 3DCRT, the impact of IMRT was small (Cohen's D: 0.03-0.29) on all scales.
Advances in RT provided a positive effect on QoL outcome, especially on swallowing-related QoL scales, for patients with HNSCC treated by combined modality therapy.
评估头颈部鳞状细胞癌（HNSCC）患者接受联合治疗后的生活质量（QoL），重点关注放疗（RT）技术进步带来的 QoL 治疗效益。
对 307 例 HNSCC 幸存者进行了 EORTC QLQ-C30 和 QLQ-H&N35 问卷的 QoL 横断面调查。135 例患者接受二维放疗（2DRT），90 例接受三维适形放疗（3DCRT），82 例接受调强放疗（IMRT）。使用 Cohen's D 系数计算组间效应大小。
年收入较高或接受更先进 RT 技术治疗的患者具有更好的 QoL 结果。与 2DRT 相比，3DCRT 对所有 QoL 量表的影响较小（Cohen's D：0.02-0.40）。对于 IMRT，大多数量表的影响较小，张口、口干和唾液粘稠的影响中等（Cohen's D：0.55-0.60）。与 3DCRT 相比，IMRT 对所有量表的影响较小（Cohen's D：0.03-0.29）。
RT 技术的进步为接受联合治疗的 HNSCC 患者的 QoL 结果提供了积极影响，特别是在吞咽相关的 QoL 量表上。
