Chromosomal abnormalities in T-cell malignant lymphoma.

Chromosomal abnormalities of T-cell malignant lymphoma are nonrandom and often complex. Some are common with those of other lymphomas, others are more characteristic for T-cell proliferations. The most frequent chromosomal breakpoints involve chromosomes 6, 1, 2, 9p, 17, and the bands where the TcR genes are localized. The frequent rearrangement of band 14q32 suggests that an oncogene is located within. The main results of molecular studies performed in T-cell malignant lymphomas are summarized.