Tillmann Thomas, Ernst Heinrich, Streckert Joachim, Zhou Yi, Taugner Felicitas, Hansen Volkert, Dasenbrock Clemens
Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.
Int J Radiat Biol. 2010 Jul;86(7):529-41. doi: 10.3109/09553001003734501.
To evaluate putative effects on tumour susceptibility in mice exposed to a UMTS (universal mobile telecommunications system) test signal for up to 24 months, commencing with embryo-fetal exposure.
Animals were exposed to UMTS fields with intensities of 0, 4.8, and 48 W/m(2), the low-dose group (4.8 W/m(2)) was subjected to additional prenatal ethylnitrosourea treatment (40 mg ENU/kg body weight).
The high-level UMTS exposure (48 W/m(2)), the sham exposure, and the cage control groups showed comparable tumour incidences in the protocol organs. In contrast, the ENU-treated group UMTS-exposed at 4.8 W/m(2) displayed an enhanced lung tumour rate and an increased incidence of lung carcinomas as compared to the controls treated with ENU only. Furthermore, tumour multiplicity of the lung carcinomas was increased and the number of metastasising lung tumours was doubled in the ENU/UMTS group as compared to the ENU control group.
This pilot study indicates a cocarcinogenic effect of lifelong UMTS exposure (4.8 W/m(2)) in female B6C3F1 descendants subjected to pretreatment with ethylnitrosourea.
评估从胚胎-胎儿期开始，让小鼠暴露于通用移动通信系统（UMTS）测试信号长达24个月对肿瘤易感性的假定影响。
将动物暴露于强度为0、4.8和48 W/m²的UMTS场，低剂量组（4.8 W/m²）额外接受产前乙基亚硝基脲处理（40 mg ENU/千克体重）。
高剂量UMTS暴露组（48 W/m²）、假暴露组和笼养对照组在方案规定的器官中显示出相当的肿瘤发生率。相比之下，与仅接受ENU处理的对照组相比，接受4.8 W/m² UMTS暴露的ENU处理组显示出更高的肺癌发生率和肺癌发病率增加。此外，与ENU对照组相比，ENU/UMTS组肺癌的肿瘤多发性增加，转移到肺部的肿瘤数量增加了一倍。
这项初步研究表明，在接受乙基亚硝基脲预处理的雌性B6C3F1后代中，终身UMTS暴露（4.8 W/m²）具有协同致癌作用。
