Institute of Physiology and Neurophysiology Research Group of the Hungarian Academy of Sciences, Pécs University Medical School, Pécs, Hungary.
Psychiatry Clin Neurosci. 2010 Aug;64(4):403-7. doi: 10.1111/j.1440-1819.2010.02106.x. Epub 2010 Jun 10.
Anorexia nervosa is a complex psychiatric disorder posing a rapidly increasing burden on modern societies. Our purpose was to clarify perceptual-motivational aspects of gustatory disturbances in the disease.
A taste reactivity test, with the use of all five primary qualities in two concentrations, was performed in restrictive-type anorexic patients, and their hedonic evaluations were compared to those of age-matched healthy control subjects.
The patients gave significantly lower pleasantness scores for pleasant taste stimuli compared with controls. The differences were the greatest for the lower concentration sucrose, umami and sodium chloride. Ratings given for the aversive taste stimuli were similar in both experimental groups.
Our findings contribute to a better understanding of complex symptoms of anorexia nervosa, and may also help to develop more effective cognitive-behavioral therapies.
神经性厌食症是一种复杂的精神障碍，给现代社会带来了迅速增加的负担。我们的目的是阐明该疾病味觉障碍的感知-动机方面。
在限制型厌食症患者中进行味觉反应测试，使用两种浓度的五种基本味觉，将其愉悦评价与年龄匹配的健康对照者进行比较。
与对照组相比，患者对愉快的味觉刺激的愉悦评分明显较低。对于较低浓度的蔗糖、鲜味和氯化钠，差异最大。两组实验对象对厌恶的味觉刺激的评分相似。
我们的发现有助于更好地理解神经性厌食症的复杂症状，也可能有助于开发更有效的认知行为疗法。
