Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, and Institute of Cardiovascular and Metabolic Research, The University of Reading, Reading RG6 6AP, UK.
Proc Nutr Soc. 2010 Aug;69(3):311-5. doi: 10.1017/S0029665110001837. Epub 2010 Jun 14.
The enrichment of immune cell membranes with n-3 PUFA is associated with modulation of immune function. The degree of incorporation of n-3 PUFA (and therefore the impact of dietary n-3 PUFA on immune function) appears to depend on a number of factors including species and age. The mechanisms involved are still largely unclear, but recent work has focused on two areas; lipid rafts and eicosanoids. In vitro studies suggest that lipid rafts could play a role in the immunomodulatory effects of n-3 PUFA, but there is still little information regarding the extent to which membrane microdomains in human lymphocytes are modulated by dietary supplementation. The enrichment of cell membranes with n-3 PUFA also modulates the production of eicosanoids, the full extent of which has not yet been realized; this represents a key area for future research.
免疫细胞膜中 n-3PUFA 的富集与免疫功能的调节有关。n-3PUFA 的掺入程度（因此，饮食中 n-3PUFA 对免疫功能的影响）似乎取决于许多因素，包括物种和年龄。涉及的机制在很大程度上仍不清楚，但最近的工作集中在两个领域：脂筏和类二十烷酸。体外研究表明，脂筏可能在 n-3PUFA 的免疫调节作用中发挥作用，但关于饮食补充对人淋巴细胞膜微区的调节程度，信息仍然很少。n-3PUFA 对细胞膜的富集也调节类二十烷酸的产生，其全部程度尚未被认识到；这是未来研究的一个关键领域。
