Quintero-Castillo Daimarys, Luz-Araujo Hedy, Guerra-Velázquez Mery, Reyna-Villasmil Eduardo, Santos Bolívar Joel, Torres-Cepeda Duly, Mejia-Montilla Jorly, Reyna-Villasmil Nadia
Servicio de Medicina Interna, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela.
Endocrinol Nutr. 2010 Jun-Jul;57(6):262-7. doi: 10.1016/j.endonu.2010.04.001. Epub 2010 May 23.
To compare lipid and lipoprotein concentrations between obese and non-obese women with a diagnosis of polycystic ovary syndrome (PCOS) treated with metformin for 6 months.
Sixty-five women with a diagnosis of PCOS were included. The presence of obesity, serum concentrations of cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) were recorded before and after 6 months of metformin treatment. The women were divided in two groups of 34 obese women (group A; body mass index >27 kg/m(2)) and 31 non-obese women (group B; body mass index (<27 kg/m(2)).
Significant differences in body mass index, waist-hip ratio, cholesterol, triglycerides, LDL-c and HDL-c were found in group A compared with group B (p<0.05). In obese women, serum triglyceride and LDL-c concentrations were significantly reduced (p<0.05), while serum concentrations of HDL-c were significantly increased (p<0.05) after 6 months of treatment. In non-obese women, none of these lipid profile modifications were considered significant (p=ns).
Metformin use for 6 months modified triglyceride, LDL-c and HDL-c concentrations compared with initial values in obese women with PCOS while no significant modifications in lipid or lipoprotein concentrations were observed in non-obese women.
比较诊断为多囊卵巢综合征（PCOS）的肥胖和非肥胖女性在接受二甲双胍治疗6个月后的血脂和脂蛋白浓度。
纳入65例诊断为PCOS的女性。记录二甲双胍治疗6个月前后肥胖情况、血清胆固醇、甘油三酯、高密度脂蛋白胆固醇（HDL-c）和低密度脂蛋白胆固醇（LDL-c）浓度。将这些女性分为两组，34例肥胖女性（A组；体重指数>27 kg/m²）和31例非肥胖女性（B组；体重指数<27 kg/m²）。
与B组相比，A组在体重指数、腰臀比、胆固醇、甘油三酯、LDL-c和HDL-c方面存在显著差异（p<0.05）。在肥胖女性中，治疗6个月后血清甘油三酯和LDL-c浓度显著降低（p<0.05），而血清HDL-c浓度显著升高（p<0.05）。在非肥胖女性中，这些血脂谱变化均无显著意义（p=无显著性差异）。
与PCOS肥胖女性的初始值相比，使用二甲双胍6个月可改变甘油三酯、LDL-c和HDL-c浓度，而非肥胖女性的血脂或脂蛋白浓度无显著变化。
