Mahabeer S, Naidoo C, Norman R J, Jialal I, Reddi K, Joubert S M
Department of Chemical Pathology, University of Natal Medical School, Durban, South Africa.
Horm Metab Res. 1990 Oct;22(10):537-40. doi: 10.1055/s-2007-1004966.
Clinical parameters, androgen status and lipoprotein lipid profiles were assessed in 10 non-obese and 10 obese patients with polycystic ovarian disease (PCOD) and reference subjects matched for age, height and weight. Both obese and non-obese women with PCOD had significantly higher androgen levels when compared to the reference groups. When comparison of lipoprotein lipid profiles were made between groups, non-obese women with PCOD had significantly higher total cholesterol, triglycerides and LDL-cholesterol levels than non-obese reference subjects. Obese PCOD women manifested significantly higher total cholesterol, LDL-cholesterol, cholesterol/HDL, and LDL/HDL values than did obese reference subjects. Correlations between serum androgens and lipoprotein lipid concentrations in PCOD and normal women were unhelpful. Both non-obese and obese patients with PCOD had significantly higher systolic and diastolic blood pressures (BPs) than the reference groups. Thus, both non-obese and obese women with PCOD manifest hyperandrogenaemia which may result in a male pattern of lipoprotein lipid concentrations.
对10名非肥胖和10名肥胖的多囊卵巢疾病（PCOD）患者以及年龄、身高和体重相匹配的对照受试者进行了临床参数、雄激素状态和脂蛋白脂质谱评估。与对照组相比，肥胖和非肥胖的PCOD女性雄激素水平均显著更高。在组间比较脂蛋白脂质谱时，患有PCOD的非肥胖女性的总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平显著高于非肥胖对照受试者。肥胖的PCOD女性的总胆固醇、低密度脂蛋白胆固醇、胆固醇/高密度脂蛋白以及低密度脂蛋白/高密度脂蛋白值显著高于肥胖对照受试者。PCOD女性和正常女性血清雄激素与脂蛋白脂质浓度之间的相关性并无帮助。非肥胖和肥胖的PCOD患者的收缩压和舒张压均显著高于对照组。因此，肥胖和非肥胖的PCOD女性均表现为高雄激素血症，这可能导致男性模式的脂蛋白脂质浓度。
