基于熟悉度的联想检索的神经关联。
Neural correlates of familiarity-based associative retrieval.
机构信息
Department of Psychology, UNC-CH, Chapel Hill, NC 27599, USA.
出版信息
Neuropsychologia. 2010 Aug;48(10):3019-25. doi: 10.1016/j.neuropsychologia.2010.06.010. Epub 2010 Jun 12.
Abstract
The current study compared the neural correlates of associative retrieval of compound (unitized) stimuli and unrelated (non-unitized) stimuli. Although associative recognition was nearly identical for compounds and unrelated pairs, accurate recognition of these different pair types was associated with activation in distinct regions within the medial temporal lobe (MTL). Recognition of previously presented compound words was associated with left perirhinal activity, whereas recognition of unrelated word pairs was associated with activity in left hippocampus. These results provide evidence that perirhinal cortex mediates familiarity-based associative memory of stimuli unitized at encoding, while the hippocampus is required for recollection-based associative memory.
摘要
当前的研究比较了复合（单元化）刺激和不相关（非单元化）刺激的联想检索的神经相关性。尽管复合词和不相关的词对的联想识别几乎相同，但对这些不同词对类型的准确识别与内侧颞叶（MTL）内不同区域的激活有关。对先前呈现的复合词的识别与左侧边缘叶活动有关，而对不相关的词对的识别与左侧海马体的活动有关。这些结果提供了证据表明，边缘叶皮层介导了在编码时对刺激的基于熟悉度的联想记忆的单元化，而海马体则是基于回忆的联想记忆所必需的。
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