University of Toronto, Canada.
Brain Lang. 2010 Sep;114(3):164-79. doi: 10.1016/j.bandl.2010.05.005. Epub 2010 Jun 14.
Functional magnetic resonance imaging (fMRI) was used to investigate the neural processing characteristics associated with word retrieval abilities after a phonologically-based treatment for anomia in two stroke patients with aphasia. Neural activity associated with a phonological and a semantic task was compared before and after treatment with fMRI. In addition to the two patients who received treatment, two patients with aphasia who did not receive treatment and 10 healthy controls were also scanned twice. In the two patients who received treatment, both of whose naming improved after treatment, results showed that activation patterns changed after treatment on the semantic task in areas that would have been expected (e.g., left hemisphere frontal and temporal areas). For one control patient, there were no significant changes in brain activation at the second scan; a second control patient showed changes in brain activation at the second scan, on the semantic task, however, these changes were not accompanied with improved performance in naming. In addition, there appeared to be bilateral, or even more right than left hemisphere brain areas activated in this patient than in the treated patients. The healthy control group showed no changes in activation at the second scan. These findings are discussed with reference to the literature on the neural underpinnings of recovery after treatment for anomia in aphasia.
功能磁共振成像（fMRI）被用于研究两名失语症患者在接受基于语音的命名障碍治疗后与单词检索能力相关的神经处理特征。使用 fMRI 在治疗前后比较了与语音和语义任务相关的神经活动。除了接受治疗的两名患者外，两名未接受治疗的失语症患者和 10 名健康对照者也进行了两次扫描。在接受治疗的两名患者中，两人的命名在治疗后均有所改善，结果表明，在语义任务上，治疗后在预期区域（例如左半球额颞区）的激活模式发生了变化。对于一名对照患者，第二次扫描时大脑激活没有明显变化；第二名对照患者在第二次扫描时的语义任务中大脑激活发生了变化，但这并没有伴随着命名表现的改善。此外，与接受治疗的患者相比，该患者的大脑激活似乎在双侧，甚至右半球比左半球更多。健康对照组在第二次扫描时没有显示出激活的变化。这些发现与失语症患者治疗后命名恢复的神经基础文献进行了讨论。
