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本文引用的文献

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Fatal infection in an infant associated with Coxsackie virus group A, type 16.一名婴儿感染16型A组柯萨奇病毒后死亡。
N Engl J Med. 1963 May 9;268:1041-4. doi: 10.1056/NEJM196305092681904.
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Report of an outbreak of febrile illness with pharyngeal lesions and exanthem: Toronto, summer 1957; isolation of group A Coxsackie virus.伴有咽部病变和皮疹的发热性疾病暴发报告：多伦多，1957年夏季；A组柯萨奇病毒的分离
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Hand, foot and mouth disease in an immunocompromised adult treated with aciclovir.
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Use of molecular assay in diagnosis of hand, foot and mouth disease caused by enterovirus 71 or coxsackievirus A 16.分子检测在肠道病毒71型或柯萨奇病毒A16型所致手足口病诊断中的应用
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Hand-foot-and-mouth disease.手足口病
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6
Hand, foot, and mouth disease. A clinically recognizable virus infection seen mainly in children.手足口病。一种临床上可识别的病毒感染，主要见于儿童。
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Hand, foot, and mouth disease: a viral disease of importance to dentists.手足口病：一种对牙医来说很重要的病毒性疾病。
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一例免疫功能正常成年人的手足口病病例

A Case of Hand-foot-mouth Disease in an Immunocompetent Adult.

作者信息

Shin Jung U, Oh Sang Ho, Lee Ju Hee

机构信息

Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Ann Dermatol. 2010 May;22(2):216-8. doi: 10.5021/ad.2010.22.2.216. Epub 2010 May 18.

DOI:10.5021/ad.2010.22.2.216
PMID:20548919
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2883431/
Abstract

Hand-foot-mouth (HFM) disease is primarily a disease of children, although it can be seen in immunocompromised adults. We describe a case of HFM disease in a 35-year-old immunocompetent male. He presented with multiple, 1~2 mm sized, erythematous vesicular papules on both hands and feet. Histopathological findings of a skin biopsy showed superficial perivascular lymphocytic infiltration, focal keratinocyte necrosis, and reticular degeneration. Because delayed diagnosis can cause spread of the disease to children, dermatologists should be aware that HFM disease can occur in adults with intact immune systems.

摘要

手足口病主要是一种儿童疾病，不过在免疫功能低下的成年人中也可见到。我们描述了一例发生在一名35岁免疫功能正常男性身上的手足口病病例。他双手和双足出现了多个大小为1至2毫米的红色水疱性丘疹。皮肤活检的组织病理学结果显示有浅表血管周围淋巴细胞浸润、局灶性角质形成细胞坏死和网状变性。由于延迟诊断可能导致疾病传播给儿童，皮肤科医生应意识到手足口病可发生于免疫系统健全的成年人。