Eisa Naseem
Community Health Partners, Fresno, CA 93720, USA.
JCEM Case Rep. 2025 May 15;3(7):luaf106. doi: 10.1210/jcemcr/luaf106. eCollection 2025 Jul.
Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy and is often characterized by a high rate of regional lymph node involvement. However, distant metastasis is uncommon, and cutaneous metastases are particularly rare, occurring in fewer than 0.1% of cases. This report presents an unusual case of isolated skin metastasis as the first manifestation of distant spread in PTC. The case highlights the diagnostic challenges associated with this rare presentation, explores potential mechanisms underlying cutaneous dissemination, and underscores the significance of a multidisciplinary approach to management. The findings emphasize the importance of long-term surveillance and meticulous pathological evaluation in patients with PTC, particularly in cases with atypical metastatic patterns.
甲状腺乳头状癌（PTC）是最常见的甲状腺恶性肿瘤，其特征通常是区域淋巴结受累率高。然而，远处转移并不常见，皮肤转移尤其罕见，发生率不到0.1%。本报告介绍了一例罕见病例，孤立性皮肤转移是PTC远处转移的首发表现。该病例突出了与这种罕见表现相关的诊断挑战，探讨了皮肤播散的潜在机制，并强调了多学科管理方法的重要性。研究结果强调了对PTC患者进行长期监测和细致病理评估的重要性，特别是在具有非典型转移模式的病例中。
