Department of Internal Medicine, Hôpital Saint-Antoine, Assistance Publique/Hôpitaux de Paris, 184 rue du Fbg Saint Antoine, 75571, Paris cedex 12, France.
Eur J Epidemiol. 2010 Jul;25(7):517-24. doi: 10.1007/s10654-010-9478-9. Epub 2010 Jun 13.
Little is known about the impact of behavioral changes after the 2003 heat wave on hydration status of elderly citizens in France. We used an administrative data file provided information about 23,022 inpatients aged > or =70 years admitted between 2000 and 2006, including vital status at discharge and Charlson comorbidity index and matched it with the result of five blood tests (sodium, potassium, glucose, urea nitrogen, creatinine) within the first 24 h after admission and with daily temperatures before admission. We then measured the prevalence of plasma tonicity (PT) <275 mOsm/l or >300 mOsm/l, blood urea nitrogen/creatinine ratio (BUNC) >100 and inhospital mortality. In 2000-2002, 2003, 2004-2006, prevalence (%) was, respectively 7.5, 8.0, 9.5 (P < 0.0001) for PT < 275 mMol/l, 8.4, 10.4, 7.2 (P < 0.0001) for PT > 300 mOsm/l, and 35.4, 30.7, 26.7 (P < 0.0001) for BUNC > 100. Inhospital mortality rate was 10.8, 10.8 and 9.0%, respectively (P < 0.0001). After adjustment for covariates, OR (95% CI) in 2004-2006 with reference to 2000-2002 was 1.26 (1.13-1.39) for PT < 275 mMol/l, 0.85 (0.76-0.94) for PT > 300 mOsm/l, and 0.65 (0.61-0.69) for BUNC > 100. Inhospital mortality risk associated with hydration disorders did not vary significantly over periods for PT < 275 mMol/l (HR 1.06 to 1.40) and PT > 300 mOsm/l (HR 1.76 to 1.96) but was lower for BUNC > 100 in 2003 (HR 1.27) than in 2000-2002 (HR 1.64) or 2004-2006 (HR 1.77) (P = 0.04). So, since the 2003 heat wave, significant shifts in prevalence of intracellular hydration disorders indicate behavioral changes with positive impact on hydration status.
关于 2003 年热浪后行为改变对法国老年公民水合状态的影响知之甚少。我们使用提供了 2000 年至 2006 年间 > 或 = 70 岁住院患者 23022 例的行政数据文件,包括出院时的生存状态和 Charlson 合并症指数,并将其与入院后 24 小时内的 5 项血液检查结果(钠、钾、葡萄糖、尿素氮、肌酐)和入院前的每日温度进行匹配。然后,我们测量了血浆渗透压(PT)<275 mOsm/l 或 >300 mOsm/l、血尿素氮/肌酐比值(BUNC)>100 和院内死亡率的患病率。2000-2002 年、2003 年、2004-2006 年的 PT < 275 mMol/l 的患病率(%)分别为 7.5、8.0、9.5(P < 0.0001),PT > 300 mOsm/l 的患病率(%)分别为 8.4、10.4、7.2(P < 0.0001),BUNC > 100 的患病率(%)分别为 35.4、30.7、26.7(P < 0.0001)。院内死亡率分别为 10.8%、10.8%和 9.0%(P < 0.0001)。在校正协变量后,2004-2006 年与 2000-2002 年相比,PT < 275 mMol/l 的 OR(95%CI)为 1.26(1.13-1.39),PT > 300 mOsm/l 的 OR(95%CI)为 0.85(0.76-0.94),BUNC > 100 的 OR(95%CI)为 0.65(0.61-0.69)。与 2000-2002 年相比,PT < 275 mMol/l(HR 1.06-1.40)和 PT > 300 mOsm/l(HR 1.76-1.96)的水合紊乱相关的院内死亡风险无显著变化,但 2003 年 BUNC > 100 的风险较低(HR 1.27),而 2000-2002 年(HR 1.64)或 2004-2006 年(HR 1.77)(P = 0.04)。因此,自 2003 年热浪以来,细胞内水合紊乱患病率的显著变化表明行为改变对水合状态产生了积极影响。