Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
Ultrasound Obstet Gynecol. 2010 Sep;36(3):268-71. doi: 10.1002/uog.7718.
To determine whether in fetuses with open spina bifida at 11-13 weeks' gestation the frontomaxillary facial angle is decreased.
The frontomaxillary facial angle was measured in 20 fetuses with open spina bifida and in 100 normal controls matched for crown-rump length (CRL) at 11 + 0 to 13 + 6 weeks and the values in the two groups were compared.
In the control group the frontomaxillary facial angle decreased significantly with CRL from a mean of 84.0 degrees at a CRL of 45 mm to 76.5 degrees at a CRL of 84 mm (SD, 3.26 degrees). In the spina bifida group the mean frontomaxillary facial angle, corrected for CRL, was 9.9 degrees lower than in the controls and it was below the 5(th) centile in 18 (90%) of the cases (P < 0.0001).
In fetuses with open spina bifida at 11-13 weeks' gestation the frontomaxillary facial angle is decreased and this measurement may be useful in early screening for this abnormality.
确定在 11-13 孕周开放性脊柱裂胎儿中，额上颌角是否减小。
测量 20 例开放性脊柱裂胎儿和 100 例与头臀长（CRL）相匹配的正常对照者（11 + 0 至 13 + 6 周）的额上颌角，比较两组的额上颌角值。
在对照组中，额上颌角随 CRL 显著减小，从 45mm CRL 的平均 84.0°减小至 84mm CRL 的 76.5°（SD，3.26°）。在脊柱裂组中，校正 CRL 后的平均额上颌角比对照组低 9.9°，18 例（90%）的病例低于第 5 百分位数（P < 0.0001）。
在 11-13 孕周开放性脊柱裂胎儿中，额上颌角减小，该测量值可能有助于早期筛查这种异常。
