Department of Experimental Psychology, University of Oxford, South Parks Road, OX1 3UD, UK.
Eur J Neurosci. 2010 Jun;31(12):2341-51. doi: 10.1111/j.1460-9568.2010.07271.x. Epub 2010 Jun 14.
It has been claimed that social behaviour changes after lesions of the ventromedial prefrontal cortex (vmPFC). However, lesions in humans are rarely restricted to a well defined cortical area. Although vmPFC lesions usually include medial orbitofrontal cortex (mOFC), they typically also affect subgenual and/or perigenual anterior cingulate cortex. The purpose of the current study is to investigate the role of mOFC in social valuation and decision-making. We tested four macaque monkeys prior to and after focal lesions of mOFC. Comparison of the animals' pre- and postoperative performance revealed that, unlike lesions of anterior cingulate gyrus (ACCg), lesions of mOFC did not induce alterations in social valuation. MOFC lesions did, however, induce mild impairments in a probabilistic two-choice decision task, which were not seen after ACCg lesions. In summary, the double dissociation between the patterns of impairment suggest that vmPFC involvement in both decision-making and social valuation may be mediated by distinct subregions centred on mOFC and ACCg respectively.
有人声称，腹内侧前额叶皮层（vmPFC）损伤后社会行为会发生变化。然而，人类的损伤很少局限于一个明确界定的皮质区域。尽管 vmPFC 损伤通常包括内侧眶额皮质（mOFC），但它们通常也会影响扣带回下区和/或旁扣带回前皮质。本研究的目的是研究 mOFC 在社会估值和决策中的作用。我们在 mOFC 局灶性损伤前后对四只猕猴进行了测试。对动物术前和术后表现的比较表明，与扣带回 gyrus （ACCg）损伤不同，mOFC 损伤不会引起社会估值的改变。然而，mOFC 损伤确实会导致概率性二选一决策任务中的轻微损伤，而 ACCg 损伤后则不会出现这种情况。总之，损伤模式的双重分离表明，vmPFC 参与决策和社会估值可能分别由以 mOFC 和 ACCg 为中心的不同亚区介导。
