Department of Therapy, Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Tartu, Estonia.
Acta Vet Scand. 2010 Jun 15;52(1):41. doi: 10.1186/1751-0147-52-41.
The aim of the study was to compare the effect of two acute puerperal metritis (APM) treatment protocols on uterine condition during the late puerperal period (5th to 7th week). Late gestation healthy cows (n = 21) were divided randomly in three equal groups. Parturitions were induced. Treatments of APM were started on the third day postpartum (PP). Group A was treated with an oxytocin analogue carbetocin for three days and intrauterine administration of cephapirin between days 15 and 17. Group B was given intramuscular injection of ceftiofur for five days followed by two injections of prostaglandin F2alpha, at an interval of 12 h, on the eighth day PP. Group C served as the control group with no treatment. Body temperature was recorded daily for 14 days PP. Uterine biopsies for bacteriology, and uterobrush samples for cytology, were taken once a week from the 5th to 7th week postpartum. No differences were found in body temperature on day 14 PP, presence of bacteriological infections and disappearance of uterine inflammatory signs diagnosed by cytological examination between experimental groups.
本研究旨在比较两种急性产后子宫内膜炎（APM）治疗方案对产后晚期（第 5 至 7 周）子宫状况的影响。选择健康的妊娠末期奶牛（n=21），随机分为三组。诱导分娩。APM 治疗于产后第 3 天开始。A 组连续 3 天使用催产素类似物卡贝缩宫素，第 15 至 17 天宫内注射头孢匹林。B 组连续 5 天肌内注射头孢噻呋，然后在第 8 天间隔 12 小时注射两次前列腺素 F2alpha。C 组为对照组，不进行治疗。产后 14 天每天记录体温。产后第 5 至 7 周每周进行一次子宫活检进行细菌学检查，以及使用子宫刷进行细胞学检查。在第 14 天产后，体温、细菌感染的存在以及通过细胞学检查诊断的子宫炎症迹象的消失在实验组之间没有差异。
