School of Public Health, University of Alberta, 3-50 University Terrace, 8303-112 Street, Edmonton, Alberta T6G2T4, Canada.
Cancer Epidemiol Biomarkers Prev. 2010 Jul;19(7):1879-81. doi: 10.1158/1055-9965.EPI-10-0356. Epub 2010 Jun 15.
A carcinogenic role of human papillomavirus (HPV) in lung cancer development has been suggested through both clinical and laboratory research during the last two decades.
We did a population-based case-control study nested within the Finnish Maternity Cohort to assess the role of HPV16/18 infections in female lung carcinogenesis. The Finnish Maternity Cohort containing samples from more than 600,000 subjects were linked with nationwide cancer registries (1973-2006). Serum samples were retrieved from 311 women who developed lung cancer and 930 matched controls. The samples were analyzed for antibodies to HPV types 16 and 18 and cotinine (a biomarker of tobacco exposure). Conditional logistic regression-based estimates of odds ratios and 95% confidence intervals adjusted for cotinine levels were calculated.
Overall, there was no evidence of increased risk of lung cancer associated with HPV 16 and 18 type-specific infections among nonsmokers and smokers, assessed via cotinine levels.
The question of HPV etiologic effect on lung carcinoma deserves further longitudinal studies using different HPV detection methods.
Our results bring new insights into female HPV lung cancer research.
在过去的二十年中，通过临床和实验室研究，已经提出了人乳头瘤病毒（HPV）在肺癌发展中的致癌作用。
我们在芬兰母婴队列中进行了一项基于人群的病例对照研究，以评估 HPV16/18 感染在女性肺癌发生中的作用。芬兰母婴队列包含了来自 60 多万名受试者的样本，并与全国癌症登记处（1973-2006 年）相关联。从 311 名患有肺癌的女性和 930 名匹配的对照者中提取血清样本。分析了针对 HPV 类型 16 和 18 的抗体和可替宁（烟草暴露的生物标志物）。计算了基于条件逻辑回归的比值比和 95%置信区间的估计值，并针对可替宁水平进行了调整。
总体而言，在非吸烟者和吸烟者中，根据可替宁水平评估，HPV16 和 18 型特异性感染与肺癌风险增加之间没有证据。
HPV 对肺癌的病因作用值得进一步进行使用不同 HPV 检测方法的纵向研究。
我们的研究结果为女性 HPV 肺癌研究带来了新的见解。
