龙舌兰科两种植物中的甾体皂苷。
Steroidal saponins from two species of Dracaena.
机构信息
Laboratoire de Pharmacognosie, Unite de Molecules d'Interet Biologique, UMIB UPRES-EA 3660, Faculte de Pharmacie, Universite de Bourgogne, 7 Boulevard Jeanne d'Arc, Dijon Cedex, France.
出版信息
J Nat Prod. 2010 Jul 23;73(7):1266-70. doi: 10.1021/np100153m.
Four new steroidal saponins (1-4) were isolated from the stem and bark of two species of Dracaena: deistelianosides A and B (1 and 2) from D. deisteliana and arboreasaponins A and B (3 and 4) from D. arborea. Six known saponins and one known sapogenin were also isolated. The structures of 1-4 were established as diosgenin 3-O-[3-O-sulfate-alpha-l-rhamnopyranosyl-(1-->4)]-beta-d-glucopyranoside (1), 1-O-beta-d-xylopyranosyl-(1-->2)-[alpha-l-rhamnopyranosyl-(1-->3)]-beta-d-fucopyranosyl(23S,24S)-spirosta-5,25(27)-diene-1beta,3beta,23alpha,24alpha-tetrol 24-O-alpha-l-arabinopyranoside (2), pennogenin-3-O-alpha-l-rhamnopyranosyl-(1-->2)-[alpha-l-rhamnopyranosyl-(1-->3)]-[6-O-acetyl]-beta-d-glucopyranoside (3), and 24alpha-hydroxypennogenin 3-O-alpha-l-rhamnopyranosyl-(1-->2)-[alpha-l-rhamnopyranosyl-(1-->3)]-beta-d-glucopyranoside (4) using extensive 1D and 2D NMR spectroscopic analyses and mass spectrometry. Cytotoxic activity of several of these compounds was evaluated against the HT-29 and HCT 116 human colon cancer cell lines.
从两种龙舌兰属植物的茎和树皮中分离得到了四种新的甾体皂苷（1-4）：来自德拉肯尼亚·德斯特利安诺斯的 deistelianosides A 和 B（1 和 2）和来自德拉肯尼亚·阿伯雷亚的 arboreasaponins A 和 B（3 和 4）。还分离得到了六种已知的皂苷和一种已知的甾体皂甙元。1-4 的结构被确定为薯蓣皂苷元 3-O-[3-O-硫酸-α-L-鼠李吡喃糖基-(1-->4)]-β-D-吡喃葡萄糖苷（1）、1-O-β-D-吡喃木糖基-(1-->2)-[α-L-鼠李吡喃糖基-(1-->3)]-β-D-岩藻吡喃糖苷（23S,24S）-螺甾烷-5,25(27)-二烯-1β,3β,23α,24α-四醇 24-O-α-L-阿拉伯吡喃糖苷（2）、羽扇豆醇-3-O-α-L-鼠李吡喃糖基-(1-->2)-[α-L-鼠李吡喃糖基-(1-->3)]-[6-O-乙酰基]-β-D-吡喃葡萄糖苷（3）和 24α-羟基羽扇豆醇 3-O-α-L-鼠李吡喃糖基-(1-->2)-[α-L-鼠李吡喃糖基-(1-->3)]-β-D-吡喃葡萄糖苷（4），使用广泛的 1D 和 2D NMR 光谱分析和质谱分析。对这些化合物中的几种化合物对 HT-29 和 HCT 116 人结肠癌细胞系的细胞毒性活性进行了评估。
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