Division of Virology, Department of Microbiology and Immunology, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
J Clin Microbiol. 2010 Aug;48(8):2872-7. doi: 10.1128/JCM.00439-10. Epub 2010 Jun 16.
Simple and rapid diagnosis of influenza is useful for making treatment decisions in the clinical setting. Although many influenza rapid diagnostic tests (IRDTs) are available for the detection of seasonal influenza virus infections, their sensitivity for other viruses, such as H5N1 viruses and the recently emerged swine origin pandemic (H1N1) 2009 virus, remains largely unknown. Here, we examined the sensitivity of 20 IRDTs to various influenza virus strains, including H5N1 and 2009 pandemic H1N1 viruses. Our results indicate that the detection sensitivity to swine origin H1N1 viruses varies widely among IRDTs, with some tests lacking sufficient sensitivity to detect the early stages of infection when the virus load is low.
快速简便地诊断流感有助于临床医生做出治疗决策。虽然有许多流感快速诊断检测试剂(IRDTs)可用于检测季节性流感病毒感染,但它们对其他病毒(如 H5N1 病毒和最近出现的猪源大流行(H1N1)2009 病毒)的敏感性在很大程度上仍不清楚。在这里,我们研究了 20 种 IRDT 对各种流感病毒株的敏感性,包括 H5N1 和 2009 年大流行 H1N1 病毒。我们的结果表明,IRDT 对猪源 H1N1 病毒的检测敏感性差异很大,有些检测方法在病毒载量较低时,无法检测到感染的早期阶段,因此灵敏度不足。